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中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (05) : 310 -313. doi: 10.3877/cma.j.issn.2095-1221.2020.05.010

所属专题： 文献；

综述

间充质干细胞及其外泌体修复电离辐射损伤的研究进展
程远航1, 陈津2, 吴卫真3,†()   
  1. 1. 350025　福州，福建省福州市厦门大学附属东方医院泌尿外科；431700　天门，湖北省天门市第一人民医院泌尿外科
    2. 350025　福州，联勤保障部队第九〇〇医院福建省干细胞应用工程技术研究中心
    3. 350025　福州，福建省福州市厦门大学附属东方医院泌尿外科
  • 收稿日期:2020-03-12 出版日期:2020-10-01
  • 通信作者: 吴卫真
  • 基金资助:
    国家自然科学基金青年项目(81601618); 福建省引导性项目(2018Y0070); 福建省自然科学基金(2016J01582，2018J01349)

Advances of mesenchymal stem cells and their exosomes in repairing ionizing radiation damage

Yuanhang Cheng1, Jin Chen2, Weizhen Wu3,†()   

  1. 1. Department of Urology, Xiamen University Affiliated East Hospital, Fuzhou 350025, China; Department of Urology, the First People's Hospital of Tianmen City, Tianmen 431700, China
    2. Fujian Provincial Stem Cell Application Engineering Technology Research Center, 900th hospital, Fuzhou 350025, China
    3. Department of Urology, Xiamen University Affiliated East Hospital, Fuzhou 350025, China
  • Received:2020-03-12 Published:2020-10-01
  • Corresponding author: Weizhen Wu
  • About author:
    Corresponding author: Wu Weizhen, Email:
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程远航, 陈津, 吴卫真. 间充质干细胞及其外泌体修复电离辐射损伤的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(05): 310-313.

Yuanhang Cheng, Jin Chen, Weizhen Wu. Advances of mesenchymal stem cells and their exosomes in repairing ionizing radiation damage[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(05): 310-313.

目前电离辐射在X射线成像、放射治疗和核电等领域应用广泛，但辐射也会对正常组织产生严重的损伤。目前虽有部分药物可用于损伤的治疗，但效果欠佳。间充质干细胞（MSC）具有迁移到病变部位促进损伤组织修复的能力，在多种不同种类电离辐射损伤的治疗中具有巨大的应用前景。MSC外泌体具有和MSC相似的功能，例如修复组织损伤，抑制炎症反应和调节免疫系统等，因此可以替代MSC用来治疗电离辐射损伤。本文将从电离辐射的生物学效应、MSC和外泌体的生物学功能以及其在电离辐射损伤修复的最新研究进展进行综述。

关键词: 电离辐射, 间充质干细胞, 外泌体

Ionizing radiation is widely used in X-ray imaging, radiotherapy and nuclear power, which would cause serious damage to normal tissue. Although some drugs can be used for the treatment of the injury, the effect is not satisfactory. Mesenchymal stem cells (MSC) have the ability to migrate to position of disease to promote the repair of damaged tissues, and have great applicational prospects in the treatment of many different types of ionizing radiation injuries. Mesenchymal stem cell exosomes have similar functions to MSC, such as repairing tissue damage, suppressing inflammatory responses and regulating the immune system. Therefore, they can be used to treat ionizing radiation injury instead of MSC. In this paper, the latest research progress on the biological effects of ionizing radiation, the biological functions and the repair of ionizing radiation damage of MSC and exosomes are reviewed.

Key words: Ionizing radiation, Mesenchymal stem cells, Exosome
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