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中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (04) : 229 -233. doi: 10.3877/cma.j.issn.2095-1221.2020.04.006

所属专题: 文献

综述

间充质干细胞对新型冠状病毒肺炎免疫损伤潜在修复作用的研究进展
马瑞琪1, 吴涛2, 赵秀华3, 张久聪4, 于晓辉4, 张茜2,()   
  1. 1. 730000 兰州,甘肃中医药大学临床医学院
    2. 730000 兰州,解放军联勤保障部队第九四〇医院血液科
    3. 西部战区疾病预防控制中心
    4. 730000 兰州,解放军联勤保障部队第九四〇医院消化科
  • 收稿日期:2020-04-15 出版日期:2020-08-01
  • 通信作者: 张茜
  • 基金资助:
    火神山医院科研面上课题(HSSYYKYMSKT-223)

Advances in the potential repairment of novel coronavirus-induced immune injury by mesenchymal stem cells

Ruiqi Ma1, Tao Wu2, Xiuhua Zhao3, Jiucong Zhang4, Xiaohui Yu4, Qian Zhang2,()   

  1. 1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
    2. Department of Hematology, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730000, China
    3. Western Theater Center for Disease Control and Prevention, Lanzhou 730000, China
    4. Department of Gastroenterology, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730000, China
  • Received:2020-04-15 Published:2020-08-01
  • Corresponding author: Qian Zhang
  • About author:
    Corresponding author:Zhang Qian, Email:
引用本文:

马瑞琪, 吴涛, 赵秀华, 张久聪, 于晓辉, 张茜. 间充质干细胞对新型冠状病毒肺炎免疫损伤潜在修复作用的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2020, 10(04): 229-233.

Ruiqi Ma, Tao Wu, Xiuhua Zhao, Jiucong Zhang, Xiaohui Yu, Qian Zhang. Advances in the potential repairment of novel coronavirus-induced immune injury by mesenchymal stem cells[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(04): 229-233.

针对新型冠状病毒肆虐以及暂无特效药物治疗的情况,多地已开展间充质干细胞(MSCs)在新型冠状病毒感染重症救治方面的临床研究,在规范应用的前提下,经过严格的临床检验后,对若干重型患者进行治疗并取得了一定效果。MSCs能抑制免疫系统过度激活,通过改善微环境促进内源性修复、抑制肺部炎症的进展达到缓解呼吸窘迫症状的目的。本文就新型冠状病毒免疫损伤的发生机制、治疗现状以及MSCs在治疗新型冠状病毒感染的潜在治疗机制作一介绍。

In response to the sweep of new coronaviruses and the absence of special drug treatments, many places have seen clinical research on mesenchymal stem cells (MSCs) in the treatment of severe infections of new coronaviruses. Based on standardized procedures and rigidclinical examinations, severe cases of the new coronavirus disease were treated with certain effects. MSCs could suppress the excessive activation of the immune system, and relieve respiratory distress by promoting endogenous repair and inhibiting pulmonary inflammation based on microenvironment improvement. This article introduces the pathogenetic mechanism and present status of treatment of new coronavirus-related immune injury, as well as the potential therapeutic mechanism of MSCs for new coronavirus infection.

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