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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2024, Vol. 14 ›› Issue (02) : 73 -82. doi: 10.3877/cma.j.issn.2095-1221.2024.02.002

论著

间充质干细胞在慢性肾脏病研究领域现状和趋势的知识图谱可视化分析
凌淑洵1, 涂玥2,†(), 刘思逸2   
  1. 1. 210017　南京中医药大学第二附属医院江苏省第二中医院肾内科
    2. 210023　南京中医药大学针灸推拿学院·养生康复学院　中医养生学教研室
  • 收稿日期:2024-01-26 出版日期:2024-04-01
  • 通信作者: 涂玥
  • 基金资助:
    国家自然科学基金(82174472); 江苏省自然科学基金委员会面上项目(BK20211298)

Visualization analysis on knowledge map of mesenchymal stem cells in the research field of chronic kidney disease

Shuxun Ling1, Yue Tu2,†(), Siyi Liu2   

  1. 1. Department of Nephrology, the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Second Chinese Medicine Hospital, Nanjing 210023, China
    2. Department of TCM Health Preservation, Acupuncture and moxibustion and Massage College·Health Preservation and Rehabilitation College, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • Received:2024-01-26 Published:2024-04-01
  • Corresponding author: Yue Tu
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引用本文：

凌淑洵, 涂玥, 刘思逸. 间充质干细胞在慢性肾脏病研究领域现状和趋势的知识图谱可视化分析[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(02): 73-82.

Shuxun Ling, Yue Tu, Siyi Liu. Visualization analysis on knowledge map of mesenchymal stem cells in the research field of chronic kidney disease[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(02): 73-82.

目的

基于间充质干细胞（MSCs）在慢性肾脏病（CKD）研究领域相关文献的系统分析，探究该领域研究现状、发展趋势及中医药的应用前景。

方法

该研究通过4个经典的国内外期刊数据库检索文献并进行筛选，利用CiteSpace 6.1.R6软件绘制知识图谱、分析相关数据。

结果

共纳入36篇中文文献，712篇英文文献；中文文献整体发文量较少；2004年至2023年每年发表文献量总体呈上升趋势；基金资助主要集中在美国、中国和德国；共纳入583位作者，尚未形成核心作者团队；共纳入57个国家，美国、中国和韩国为核心研究国家，美国、中国、韩国和沙特在研究中起到重要的链接作用；共被引频次最高的期刊是《KIDNEY INTERNATIONAL》，但尚未形成核心期刊；高频被引文献都是2009年以后发表，包括实验研究、临床研究和综述三类；共纳入548个关键词，聚类关键词首位是肾脏纤维化。

结论

近年来MSCs在CKD领域的研究呈多作者、多团队的加速发展趋势，中国是本领域的核心研究国家之一，起到重要的链接作用。

关键词: 间充质干细胞, 慢性肾脏病, CiteSpace, 知识图谱, 可视化分析
Objective

Based on the literature on mesenchymal stem cells (MSCs) in the research field of chronic kidney disease (CKD) , this study made the systematic visualization analysis to explore the current status, hotspots and trends, and further speculate on the application of traditional Chinese medicine (TCM) in this field.

Methods

The literature was searched and filtered by four classic domestic and international journal databases. CiteSpace 6.1.R6 software was used to draw knowledge domain maps and analyze the data.

Results

A total of 36 Chinese articles and 712 English articles were included; The overall number of Chinese articles was small. From 2004 to 2023, the mmber of published articles per year generally showed an upward trend. Grants were mainly concentrated in the USA, China, and Germany. A total of 583 authors were included, but the core team of authors had not been formed yet. A total of 57 countries were included. Further, the USA, China, and Korea were the core research countries, and the USA, China, Korea, and Saudi Arabia played important linking roles in the research. The co-cited journal with the highest frequency was KIDNEY INTERNATIONAL. However, no core journals had been established in this research area. The references with the frequency citations were all published after 2009, and they included three categories: experimental studies, clinical studies and reviews. A total of 548 keywords were included. The top 1 clustering keyword was renal fibrosis. The hotspots of recent years were "microvesicles", "exosomes", and "inflammation".

Conclusion

In recent years, studies on MSCs in the research field of CKD have shown an accelerating trend of multi-authors and multi-teams. China was one of the core research countries in this field and played an essential linking role. Their hotspots focus on "microvesicles", "exosomes", and "inflammation".

Key words: Mesenchymal stem cells, Chronic kidney disease, CiteSpace, Knowledge map, Visualization analysis
图1 2004年至2023年年度发文量折线图
图2 作者合作关系图谱
表1 发文量与共被引前5的作者
序号 作者发文量 作者共被引
作者 发文量（篇） 作者 被引频次
1 Lerman LO 24 Togel F 148
2 Eirin A 16 Morigi M 135
3 Lee SH 12 Humphreys BD 130
4 Lee JH 9 Bruno S 106
5 Lerman A 8 Eirin A 104
图3 国家合作关系图谱
图4 机构合作关系图谱
表2 发文量前10的国家和机构
序号 发文量前10的国家 发文量前10的机构
国家地区 中心性 发文量 首篇论文发表时间 机构 中心性 发文量 首篇论文发表时间
1 美国 0.62 198 2005 Mayo Clin 0.02 31 2012
2 中国 0.27 182 2011 Soonchunhyang Univ 0 16 2009
3 意大利 0.14 55 2004 China Med Univ 0.01 13 2014
4 德国 0.03 47 2006 Chang Gung Univ 0.01 11 2012
5 日本 0.03 47 2005 Brigham & Womens Hosp 0.01 10 2011
6 韩国 0.02 46 2009 Leiden Univ 0 10 2010
7 巴西 0 32 2008 Monash Univ 0 10 2007
8 新西兰 0.13 25 2010 Chinese Peoples Liberat Army Gen Hosp 0.01 9 2019
9 澳大利亚 0 25 2007 Asia Univ 0 9 2019
10 台湾 0.01 23 2012 Cent South Univ 0 8 2018
表3 共被引频次排名前6的被引文献
序号 共被引频次 文献题目 作者/国家 年份
1 46 Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation Eirin A/美国 2017
2 28 Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial Tan JM/中国 2012
3 28 Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model Semedo P/巴西 2009
4 27 Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy Grange C/意大利 2019
5 25 Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence Peired AJ/意大利 2016
图5 关键词共现图谱
图6 关键词聚类时间线图
表4 关键词聚类分析信息表
序号 聚类号聚类内论文（篇） 聚类内论文（篇） 轮廓值（S） 评价年份 基于LLR算法的聚类标签
1 #0 93 0.615 2014 renal fibrosis
2 #1 84 0.721 2016 mesenchymal stem-cells exosome
3 #2 80 0.654 2013 risks mechanism
4 #3 80 0.648 2014 organ transplantation
5 #4 62 0.793 2009 rat model
6 #5 56 0.643 2018 residual renal function
7 #6 33 0.971 2005 human mesenchymal stem cell
8 #7 28 0.851 2014 marrow-derived msc
9 #8 13 0.963 2010 interventional therapy
10 #9 12 0.915 2018 mixing cell
11 #10 3 1 2021 bone formation
12 #11 2 1 2023 aging
图7 关键词突现分析图谱
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