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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 240 -243. doi: 10.3877/cma.j.issn.2095-1221.2018.04.009

所属专题: 文献

综述

间充质干细胞旁分泌作用的研究进展
刘湄漪1, 陈乃耀1,()   
  1. 1. 063000 唐山,华北理工大学附属医院血液内科
  • 收稿日期:2018-03-31 出版日期:2018-08-01
  • 通信作者: 陈乃耀

Research progress on paracrine effect of mesenchymal stem cells

Meiyi Liu1, Naiyao Chen1,()   

  1. 1. Affiliated Hospital of North China University of Technology, Tangshan 063000, China
  • Received:2018-03-31 Published:2018-08-01
  • Corresponding author: Naiyao Chen
  • About author:
    Corresponding author: Chen Naiyao, Email:
引用本文:

刘湄漪, 陈乃耀. 间充质干细胞旁分泌作用的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2018, 08(04): 240-243.

Meiyi Liu, Naiyao Chen. Research progress on paracrine effect of mesenchymal stem cells[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 240-243.

间充质干细胞(MSCs)通常利用多分化特性在组织损伤时起到修复功能。然而,近期研究表明,MSCs大多数治疗作用都是通过旁分泌来发挥作用的,其中最受关注的是可溶性蛋白分泌和细胞外膜泡(EVS)。MSCs释放的EVS可反映细胞的来源,能够影响局部微环境中其他细胞的活动。越来越多人提出利用MSCs分泌的各种因子(称为分泌体)替代MSCs细胞治疗的观点。现就MSCs旁分泌特性、分泌体发生和释放机制以及细胞来源对旁分泌影响等方面的研究进展进行综述。

Mesenchymal stem cell (MSCs) usually uses multiple mechanisms to repair tissue damage including differentiation. However, recent studies show that the therapeutic effects of MSCs are mainly mediated by paracrine, among which soluble protein secretion and extracellular membrane vesicles (EVS) are of the greatest concern. EVs released by MSCs are reflective of their cells of origin, able to impact upon the activities of other cells in the local microenvironment. Growing evidence suggests that cytokines secreted by MSCs (called secretome) can replace MSCs cells. Here, we review the paracrine characteristics of MSCs, the mechanism of secretome generation and release, and the effects of cell sources on paracrine.

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