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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2022, Vol. 12 ›› Issue (06) : 372 -377. doi: 10.3877/cma.j.issn.2095-1221.2022.06.008

综述

间充质干细胞与巨噬细胞相互作用机制的研究进展
陈彤1, 张帆2, 房橙橙1, 李全海1, 闫宝勇2, 张君2,†()   
  1. 1. 050030　石家庄，河北医科大学第一医院细胞治疗实验室；050011　石家庄，河北医科大学免疫教研室
    2. 050030　石家庄，河北医科大学第一医院细胞治疗实验室
  • 收稿日期:2022-05-06 出版日期:2022-12-01
  • 通信作者: 张君
  • 基金资助:
    河北省自然科学基金资助(C2020206032); 温州市重大科技创新攻关项目资助(ZY2022027)

Research progress in the interaction mechanism between mesenchymalstem cells and macrophages

Tong Chen1, Fan Zhang2, Chengcheng Fang1, Quanhai Li1, Baoyong Yan2, Jun Zhang2,†()   

  1. 1. Laboratory of Cell Therapy, First Hospital of Hebei Medical University, Shijiazhuang 050030, China; Department of Immunology, Hebei Medical University, Shijiazhuang 050011, China
    2. Laboratory of Cell Therapy, First Hospital of Hebei Medical University, Shijiazhuang 050030, China
  • Received:2022-05-06 Published:2022-12-01
  • Corresponding author: Jun Zhang
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引用本文：

陈彤, 张帆, 房橙橙, 李全海, 闫宝勇, 张君. 间充质干细胞与巨噬细胞相互作用机制的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(06): 372-377.

Tong Chen, Fan Zhang, Chengcheng Fang, Quanhai Li, Baoyong Yan, Jun Zhang. Research progress in the interaction mechanism between mesenchymalstem cells and macrophages[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(06): 372-377.

间充质干细胞（MSCs）主要通过旁分泌作用于免疫细胞而参与组织修复与重塑。巨噬细胞具有吞噬杀伤和免疫调节功能，与组织细胞协调应对病理和生理应激。在炎症反应中，MSCs能借助多种方式使促炎的M1型巨噬细胞向抗炎的M2型巨噬细胞转化，调控炎症因子、抑制炎症反应和减少组织细胞损伤；同时，炎症微环境中的巨噬细胞释放多种因子也对MSCs的生物学功能产生影响。本文综述了MSCs和巨噬细胞相互作用机制及双方信息交换的研究进展，涉及细胞因子分泌、旁分泌和细胞间直接接触等方式，为优化MSCs生物学功能、修复炎症性组织损伤提供策略和方案。

关键词: 间充质干细胞, 巨噬细胞, 炎症反应, 相互作用机制

Mesenchymal stem cells (MSCs) mainly act on immune cells through the paracrine and participate in tissue repair and remodelling. Macrophages have the functions of phagocytosis and immune regulation and coordinate with many types of cells to cope with pathophysiological stress. In the inflammatory response, MSCs transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages in a variety of ways, regulate inflammatory factors, inhibit inflammatory responses and reduce tissue cell damage; At the same time, the release of multiple factors by macrophages in the inflammatory microenvironment also affects the biological function of MSCs. This review summarises the interaction mechanism between MSCs and macrophages, and the latest research progress in their information exchange, involving cytokine secretion, paracrine and intercellular direct contact. It will provide the strategy and scheme for optimizing MSCs' function to repair inflammatory tissue damage.

Key words: Mesenchymal stem cells, Macrophages, Inflammatory response, Interaction mechanism
图1 间充质干细胞对巨噬细胞极化的调节机制注：PGE2为前列腺素-E2；COX-2为环氧化酶-2；IL-6为白细胞介素6；IL-6R为白细胞介素6受体；JAK激酶为非受体型酪氨酸蛋白激酶；STAT3为信号转导和转录激活因子3；miR-204为小非编码RNA-204；IL-1为白细胞介素1；IL-1RA为IL -1受体拮抗剂；TSG-6为肿瘤坏死因子诱导蛋白-6；CD44为归巢细胞黏附分子；IDO为吲哚胺-2，3-双加氧酶；IL-10为白细胞介素10
图2 巨噬细胞对MSCs成脂成骨能力的调节机制注：miR-690为小非编码RNA-690；miR-155为小非编码RNA-155；CXCR2为趋化因子受体2；PGE2为前列腺素-E2；EP2/EP4为E型前列腺素受体2/4；TNF-α为肿瘤坏死因子-α；BMP-2为骨形态发生蛋白2
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