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中华细胞与干细胞杂志(电子版) ›› 2022, Vol. 12 ›› Issue (06) : 367 -371. doi: 10.3877/cma.j.issn.2095-1221.2022.06.007

综述

肠道菌群代谢产物与间充质干细胞相互作用的研究进展
彭聪1, 罗晓英1, 白阳秋1, 江小柯1, 张炳勇1,()   
  1. 1. 450003 郑州,河南省人民医院 (郑州大学人民医院)消化内科
  • 收稿日期:2022-04-22 出版日期:2022-12-01
  • 通信作者: 张炳勇
  • 基金资助:
    河南省卫健委医学科技攻关省部共建重大项目(SBGJ202001002)

Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells

Cong Peng1, Xiaoying Luo1, Yangqiu Bai1, Xiaoke Jiang1, Bingyong Zhang1,()   

  1. 1. Department of Gastroenterology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China
  • Received:2022-04-22 Published:2022-12-01
  • Corresponding author: Bingyong Zhang
引用本文:

彭聪, 罗晓英, 白阳秋, 江小柯, 张炳勇. 肠道菌群代谢产物与间充质干细胞相互作用的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2022, 12(06): 367-371.

Cong Peng, Xiaoying Luo, Yangqiu Bai, Xiaoke Jiang, Bingyong Zhang. Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(06): 367-371.

间充质干细胞(MSCs)具有增殖分化和调节免疫的作用,在治疗多种自身免疫性疾病的过程中表现出良好的效果,应用前景广阔。多项研究显示肠道菌群的代谢产物可以影响MSCs的功能,而MSCs亦可对肠道菌群代谢产物的生成进行调控。本文就一些常见的肠道菌群代谢产物(短链脂肪酸、氧化三甲胺、胆汁酸和色氨酸代谢物)与MSCs的相互作用进行归纳总结,并探讨基于肠道菌群代谢产物靶向调控MSCs的可行策略,为包括自身免疫性疾病在内的多种疾病的研究提供新思路。

Due to the function of proliferation, differentiation and immune regulation, mesenchymal stem cells (MSCs) have broad application prospects and currently show promising results in treating various autoimmune diseases. Related research shows that the metabolites of intestinal flora affect the function of MSCs, and MSCs also regulate the production of intestinal flora metabolites. Based on previous studies, this article reviews the interaction between some common intestinal flora metabolites (short-chain fatty acids, trimethylamine oxide, bile acids, and tryptophan metabolites) and MSCs. In addition, some feasible strategies for targeted regulation of MSCs based on intestinal flora metabolites are discussed, which can provide new ideas for studying various diseases, including autoimmune diseases.

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