Development of neural tube-like models derived from pluripotent stem cells in vitro

doi:10.3877/cma.j.issn.2095-1221.2022.01.008

Abstract

Abstract:

The approaches for culture and differentiation of pluripotent stem cells in vitro have developed rapidly, and have widely applied in the fields of regenerative medicine and developmental biology. Neural tube-like models can be established from pluripotent stem cells in vitro under neural induction, which provide a new experimental platform for exploring early neural development in vivo, and it is also benefit for exploring the mechanisms of central neural system developmental diseases. Herein, we summarized the progress of neural tube-like models derived from mouse and human pluripotent stem cells in vitro, so as to find the prospects and challenges of neural tube-like models in investigating the mechanism of neural system developmental diseases, and also can provide novel insights into for disease prevention and treatment.

Key words: Pluripotent stem cells, Organoids, Neural tube, Neural induction

Xiaozuo Zhang, Haiqin Huo, Jianxin Tan, Fang Zhang, Haoyang Feng, Zhengfeng Xu. Development of neural tube-like models derived from pluripotent stem cells in vitro[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(01): 45-50.

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References 41

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