Advances in molecular mechanisms underlying tumor metastasis and its targeted intervention

doi:10.3877/cma.j.issn.2095-1221.2022.01.009

Abstract

Abstract:

Metastasis is a multistage malignant process in which cancer cells escape from the primary tumor, invade into and survive in the circulation, arrive at and seed in distant target organs, colonize ultimately and grow into metastases. Each stage of metastatic process is involved in genetic as well as epigenetic changes of tumor cells themselves and subjected to comprehensive regulation by interaction between tumor cells and microenvironment. In this review, we summarize the recent advances in molecular mechanisms underlying the multiple stages of tumor metastasis and its targeted intervention. We also discuss a brief prospect of novel experimental technique and future directions of research in tumor metastasis.

Key words: Tumor metastasis, Molecular mechanism, Targeted intervention, Epithelial-mesenchymal transition, Tumor microenvironment

Zhuolin Li, Ruxue Jia, Yating Wu, Shenghang Zhang, Shuiliang Wang. Advances in molecular mechanisms underlying tumor metastasis and its targeted intervention[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(01): 51-58.

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