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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (05) : 310 -314. doi: 10.3877/cma.j.issn.2095-1221.2018.05.009

所属专题： 文献；

综述

iPSCs来源的血细胞在血液系统疾病中的应用与发展
谷雷1, 林静2, 王永春3, 刘玮4, 文文4, 赖国祥4, 柳德灵4, 刘月彬4, 陈津5, 杨忠6,†()   
  1. 1. 350108　福州，福建医科大学研究生院；350025　福州，福建医科大学福总临床医学院呼吸与危重症医学科
    2. 350108　福州，福建医科大学研究生院
    3. 748000　定西，中国人民解放军31658部队
    4. 350025　福州，福建医科大学福总临床医学院呼吸与危重症医学科
    5. 350025　福州总医院全军器官移植中心，福建省移植生物学重点实验室
    6. 400038　重庆，陆军军医大学西南医院检验系临床血液学教研室
  • 收稿日期:2018-05-11 出版日期:2018-10-01
  • 通信作者: 杨忠
  • 基金资助:
    福建省科技计划重点项目(2014Y0037); 福建省临床重点专科建设项目(闽卫医政函（2015）593号)

Applications and development of induced-pluripotent-stem-cell-derived hematopoietic cells in hematological diseases

Lei Gu1, Jing Lin2, Yongchun Wang3, Wei Liu4, Wen Wen4, Guoxiang Lai4, Deling Liu4, Yuebin Liu4, Jin Chen5, Zhong Yang6,†()   

  1. 1. Graduate College of Fujian Medical University, Fuzhou 350108, China; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital, Clinical Medicine College of Fujian Medical University, Fuzhou 350025, China
    2. Graduate College of Fujian Medical University, Fuzhou 350108, China
    3. 31658 Army of PLA, Dingxi 748000, China
    4. Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital, Clinical Medicine College of Fujian Medical University, Fuzhou 350025, China
    5. Organ Transplant Institute of PLA and Fujian provincial Key Laboratory of Transplant Biology, Fuzhou 350025, China
    6. Department of Clinical Hematology, Faculty of Laboratory Medicine, Southwest Hospital, Army Medical University, Chongqing 400038, China
  • Received:2018-05-11 Published:2018-10-01
  • Corresponding author: Zhong Yang
  • About author:
    Corresponding author:Yang Zhong, Email:
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谷雷, 林静, 王永春, 刘玮, 文文, 赖国祥, 柳德灵, 刘月彬, 陈津, 杨忠. iPSCs来源的血细胞在血液系统疾病中的应用与发展[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(05): 310-314.

Lei Gu, Jing Lin, Yongchun Wang, Wei Liu, Wen Wen, Guoxiang Lai, Deling Liu, Yuebin Liu, Jin Chen, Zhong Yang. Applications and development of induced-pluripotent-stem-cell-derived hematopoietic cells in hematological diseases[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(05): 310-314.

骨髓（BM）移植已在许多血液病中成功应用多年，主要依赖于成人BM和外周血（PB）中的造血干细胞（HSCs）。然而，合适配型HSCs的稀缺限制了其临床应用，难以满足更多有需要的患者。诱导多能干细胞（iPSCs）的出现，有望解决这一难题。iPSCs具有分化成所有血细胞的潜能，使得HSCs和其他血细胞在血液病中的广泛应用成为可能。然而，临床应用iPSCs治疗血液病仍障碍重重。本文主要回顾了iPSCs在血液病中的应用和发展以及面临的问题和挑战。

关键词: 诱导多能干细胞, 血液病, 疾病模型, 输血治疗

Bone marrow (BM) transplantation has been successfully used in many hematological diseases for several years, which mainly depends on hematopoietic stem cells (HSCs) from adult BM and peripheral blood (PB). However, the rarity of HSCs with appropriate matching has limited their applications to patients. Fortunately, the advent of iPSCs, which have the potential to differentiate into all cell types of the hematopoietic system, makes the wide applications of HSCs and other blood cells in hematology possible. However, there are still many barriers in using iPSCs in treating hematological diseases. This article mainly reviews the applications, development and some unsolved issues and challenges of iPSCs in hematology.

Key words: Induced pluripotent stem cells, Hematopoietic disease, Disease modeling, Therapeutic transfusion
图1 iPSCs在血液系统疾病中的应用
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