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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (05) : 303 -309. doi: 10.3877/cma.j.issn.2095-1221.2018.05.008

所属专题: 文献

综述

CAR-NK治疗肿瘤的研究与临床进展
刘兵1, 周美龄1, 刘韬1,()   
  1. 1. 518001 深圳市罗湖区人民医院(深圳大学第三附属医院)肿瘤内科肿瘤生物治疗组
  • 收稿日期:2018-08-03 出版日期:2018-10-01
  • 通信作者: 刘韬

CAR-NK immunotherapy for tumor: pre-clinical and clinical research

Bing Liu1, Meiling Zhou1, Tao Liu1,()   

  1. 1. Department of Biotherapy and Oncology, Shenzhen Luohu People's Hospital, the 3rd Affiliated Hospital of Shenzhen University, Shenzhen 518001, China
  • Received:2018-08-03 Published:2018-10-01
  • Corresponding author: Tao Liu
  • About author:
    Corresponding author:Liu Tao, Email:
引用本文:

刘兵, 周美龄, 刘韬. CAR-NK治疗肿瘤的研究与临床进展[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(05): 303-309.

Bing Liu, Meiling Zhou, Tao Liu. CAR-NK immunotherapy for tumor: pre-clinical and clinical research[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(05): 303-309.

肿瘤细胞免疫疗法近年来的发展颇为瞩目,嵌合抗原受体T(CAR-T)的临床研究显示其对血液系统肿瘤具有良好的治疗效果。自然杀伤细胞(NK)是人体固有免疫的一类重要细胞,其不同于T细胞的非特异性识靶及杀伤机制吸引科学家将工程CAR-T技术沿袭并用于嵌合抗原受体NK(CAR-NK)改造。目前,无论在体外细胞模型还是小鼠动物模型中,CAR-?NK均显示出良好的肿瘤杀伤效果。最新的临床研究显示,CAR-NK细胞对血液系统肿瘤有良好的治疗效果,但治疗实体瘤效果尚待验证。与CAR-T细胞疗法一样,CAR-NK也有问题亟需解决,但是NK细胞作为效应细胞,其自身优点预示CAR-NK细胞在实体瘤治疗方面拥有良好的发展前景。

Cancer immunotherapy attracts great attention in recent years. Chimeric antigen receptor (CAR) engineered T cell immunotherapy is effective for hematologic malignancies with reliable clinical results. Natural killer cells (NK) is one kind of important innate immune cells which have advantages in the treatment of solid tumor. Both in vitro and in mouse models, CAR-NK have shown encouraging antitumor effects. Current clinical trials show that CAR-NK cells have great therapeutic potential for hematologic malignancies. Although there are bottlenecks that need to be overcome for CAR-NK to treat solid tumors, the future of CAR-NK cells is promising.

图1 嵌合抗原受体结构
表1 用于NK细胞基因修饰的CAR结构
表2 常见CAR-NK构建使用病毒载体特性
表3 NK细胞来源
表4 CAR-T与CAR-NK比较
表5 NK细胞用于肿瘤治疗临床案例
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