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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (04) : 251 -256. doi: 10.3877/cma.j.issn.2095-1221.2020.04.010

所属专题： 文献；

综述

嵌合抗原受体T细胞免疫疗法的研究进展
罗宇希1, 李菲菲2, 刘康3,†(), 何治尧4   
  1. 1. 230032　合肥，安徽医科大学第一临床医学院；637000　南充，四川省南充市中心医院（川北医学院第二临床学院）组织工程与干细胞研究所肿瘤生物治疗南充市重点实验室
    2. 230032　合肥，安徽医科大学基础医学院病理生理学教研室
    3. 637000　南充，四川省南充市中心医院（川北医学院第二临床学院）组织工程与干细胞研究所肿瘤生物治疗南充市重点实验室
    4. 610041　成都，四川大学华西医院临床药学部
  • 收稿日期:2020-03-26 出版日期:2020-08-01
  • 通信作者: 刘康
  • 基金资助:
    国家级大学生创新创业训练项目(202010366031); 四川省科技计划项目(2018SZ0377，2018JY0219); 南充市市校合作科研专项(NSMC20170460); 四川省卫生健康委员会科研课题(19PJ057)

Research advances in chimeric antigen receptor-modified T cells therapy

Yuxi Luo1, Feifei Li2, Kang Liu3,†(), Zhiyao He4   

  1. 1. the First Clinical College of Anhui Medical University, Hefei 230032, China; Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College, Cancer Biotherapy Key Laboratory of Nanchong, Nanchong 637000, China
    2. Department of Pathophysiology, Anhui Medical University, Hefei 230032, China
    3. Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College, Cancer Biotherapy Key Laboratory of Nanchong, Nanchong 637000, China
    4. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2020-03-26 Published:2020-08-01
  • Corresponding author: Kang Liu
  • About author:
    Corresponding author: Liu Kang, Email:
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引用本文：

罗宇希, 李菲菲, 刘康, 何治尧. 嵌合抗原受体T细胞免疫疗法的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(04): 251-256.

Yuxi Luo, Feifei Li, Kang Liu, Zhiyao He. Research advances in chimeric antigen receptor-modified T cells therapy[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(04): 251-256.

嵌合抗原受体T （CAR-T）细胞是经基因工程修饰后表达靶向肿瘤细胞CAR分子的T细胞。CAR-T细胞治疗在血液肿瘤治疗中展现了显著的疗效而备受关注，是一种新的肿瘤免疫疗法。目前，CAR-T细胞治疗在实体瘤治疗中还面临着很大的挑战。而且，在临床应用的过程中仍会出现一些不良反应，如细胞因子释放综合征、神经毒性、归巢障碍、溶瘤综合征及脱靶效应等。本文就CAR-T疗法的基本原理及临床应用与不良反应展开做一综述。

关键词: 嵌合抗原受体T细胞, 肿瘤, 细胞过继免疫治疗

Chimeric antigen receptor-modified T (CAR-T) cells are genetically engineered T cells to express CAR molecules targeting specific surface antigens on tumor cells. CAR-T cell therapy, a novel cancer immunotherapy, has attracted much attention since it had exhibited dramatic efficacy in the treatment of hematological tumors in clinic. At present, CAR-T cell therapy still faces great challenges in the treatment of solid tumors. Furthermore, some side effects can be found in the clinical application, such as cytokine release syndrome, neurotoxicity, homing disorder, tumor lysis syndrome and on target off tumor toxicity. This review will focus on some main aspects about CAR-T cells, including the principle, clinical application and adverse events of this therapy.

Key words: CAR-T cells, Tumor, Adoptive cellular immunotherapy
图1 CAR的结构示意图
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