Effect and mechanism of mesenchymal stem cells for aortic aneurysm

doi:10.3877/cma.j.issn.2095-1221.2017.03.010

Abstract

Abstract:

Aortic aneurysm (AA) is a severe cardiovascular disease endangering human health and has an extremely high mortality rate when rupture occurs. Current treatment for AA is mainly through surgery. However, the risk of open surgery is high. While endovascular treatment is minimally invasive, its use limited due to anatomical complexity and long-term management. Therefore, it is necessary to explore new methods for early interventions. Generally, AA is due to the imbalance of extracellular matrix (ECM) synthesis and degradation in aortic wall. Chronic inflammation especially atherosclerosis can directly or indirectly promote the degradation process, which is an important factor in the pathogenesis of AA. Mesenchymal stem cells (MSC) have anti-inflammatory, immunosuppressive properties and homing capacity, ie, migrating to the site of injury, showing unique advantages for AA treatment. This review is about the mechanism of MSC as a treatment for AA.

Key words: Mesenchymal stem cell, Aortic aneurysm

Junlin Yang, Lefeng Qu. Effect and mechanism of mesenchymal stem cells for aortic aneurysm[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(03): 173-177.

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