Application and research progress of mesenchymal stem cells in spinal cord injury

doi:10.3877/cma.j.issn.2095-1221.2024.02.007

Abstract

Abstract:

Spinal cord injury (SCI) is a kind of central nervous system disorder with sensory and motor impairments below the injury level, severely affecting the self-care ability and life quality of patients. The current treatment for SCI fails to meet neural regeneration and functional recovery demands. Mesenchymal stem cells (MSCs) can differentiate multi-directionally and exert neurotrophic, immunomodulatory, and angiogenic activities through paracrine effects. MSCs and their derivatives have become attractive biological therapies for spinal cord injury, and the development of novel biomaterials has further promoted the development of related therapeutic strategies. This review summarizes the therapeutic effect and application progress of MSCs in SCI, aiming to provide insights and references for future research.

Key words: Spinal cord injury, Mesenchymal stem cell, Neural differentiation, Paracrine effect, Biomaterial

Shuili Jing, Juan Wang, Ye Liu, Heng Zhou, Wei Xiong, Qingsong Ye. Application and research progress of mesenchymal stem cells in spinal cord injury[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(02): 113-121.

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References 85

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NCT02481440	hUC-MSCs反复蛛网膜下腔给药治疗脊髓损伤	2018-03 /完成	Ⅰ/Ⅱ期	中国
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NCT03308565	脂肪干细胞治疗创伤性脊髓损伤	2017-12 /完成	Ⅰ期	美国
NCT04288934	用（autoBMMSCs）与（WJ-MSCs）治疗脊髓损伤	2017-08 /完成	Ⅰ期	约旦
NCT01274975	脊髓损伤患者的自体脂肪来源的间充质干细胞移植	2009-07 /完成	Ⅰ期	未知
NCT03979742	脐带血细胞移植到受伤的脊髓中加之运动训练	2022-02 /招募	Ⅱ期	美国
NCT04520373	自体脂肪来源的间充质干细胞用于脊髓损伤患者	2020-06 /招募	Ⅱ期	美国
NCT0176987	脂肪组织间充质干细胞植入脊髓损伤患者的安全性和效果	2016-01 /完成	Ⅰ/Ⅱ期	韩国
NCT01186679	自体骨髓干细胞治疗脊髓损伤的安全性和有效性	2008-01 /完成	Ⅰ/Ⅱ期	印度
NCT01624779	脊髓损伤患者自体脂肪组织来源的MSC鞘内移植	2012-04 /完成	Ⅰ期	韩国
NCT05693181	脐带血细胞用于急性脊髓损伤患者	2022-12 /招募	Ⅰ/Ⅱ期	俄罗斯
NCT03003364	扩增脐带沃顿胶间充质干细胞在慢性创伤性脊髓损伤中的鞘内给药	2016-12 /完成	Ⅰ/Ⅱ期	西班牙
NCT00816803	细胞脊髓损伤患者的移植	2005-05 /埃及	Ⅰ/Ⅱ期	埃及
NCT04331405	脐带血细胞用于成人严重急性挫伤脊髓损伤	2013-03 /完成	Ⅰ/Ⅱ期	俄罗斯

研究	细胞类型	形式	生物支架类型	对象
2023，Su等^[64]	ADMSCs	细胞	dECM支架	大鼠急性完全性SCI模型
2023，Zhou等^[11]	DPSCs	细胞	GelMA水凝胶	大鼠急性完全性SCI模型
2023，He等^[66]	UCMSCs	细胞	dECM支架	大鼠急性完全性SCI模型
2022，Chen等^[67]	UCMSCs	分泌组	胶原蛋白支架	大鼠急性完全性SCI模型
2022，Tang等^[69]	BMMSCs、UCMSCs	细胞	胶原蛋白支架	急性完全性SCI、慢性完全性SCI患者
2021，Zhang等^[70]	UCMSCs	外泌体	胶原蛋白支架	大鼠急性完全性SCI模型
2020，Li等^[71]	hPMSCs	外泌体	透明质酸支架	大鼠急性完全性SCI模型
2018，Mukhamedshina等^[72]	ADMSCs	细胞	纤维蛋白支架	大鼠急性完全性SCI模型
2018，Zaviskova等^[73]	hWJMSCs	细胞	透明质酸衍生支架	大鼠急性和亚急性半切SCI模型
2018，Xiao等^[74]	BMMSCs	细胞	胶原蛋白支架	急性完全性SCI患者
2018，Wang等^[75]	UCMSCs	细胞	胶原蛋白支架	大鼠慢性完全性SCI模型
2018，Peng等^[76]	BMMSCs	细胞	胶原蛋白支架	大鼠急性半切SCI模型
2018，Ma等^[77]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型
2017，Yang等^[78]	BMMSCs	细胞	聚（乳酸-乙醇酸）支架	大鼠急性完全性SCI模型
2017，Li等^[79]	UCMSCs	细胞	胶原蛋白支架	犬慢性完全性SCI模型
2017，Li等^[80]	BMMSCs	细胞	透明质酸支架	大鼠急性完全性SCI模型
2016，Li等^[81]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型、犬急性半切SCI模型
2014，Zhang等^[82]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型
2012，Cholas等^[83]	BMMSCs	细胞	胶原蛋白支架	大鼠急性半切SCI模型

研究	细胞类型	形式	生物支架类型	对象
2023，Su等^[64]	ADMSCs	细胞	dECM支架	大鼠急性完全性SCI模型
2023，Zhou等^[11]	DPSCs	细胞	GelMA水凝胶	大鼠急性完全性SCI模型
2023，He等^[66]	UCMSCs	细胞	dECM支架	大鼠急性完全性SCI模型
2022，Chen等^[67]	UCMSCs	分泌组	胶原蛋白支架	大鼠急性完全性SCI模型
2022，Tang等^[69]	BMMSCs、UCMSCs	细胞	胶原蛋白支架	急性完全性SCI、慢性完全性SCI患者
2021，Zhang等^[70]	UCMSCs	外泌体	胶原蛋白支架	大鼠急性完全性SCI模型
2020，Li等^[71]	hPMSCs	外泌体	透明质酸支架	大鼠急性完全性SCI模型
2018，Mukhamedshina等^[72]	ADMSCs	细胞	纤维蛋白支架	大鼠急性完全性SCI模型
2018，Zaviskova等^[73]	hWJMSCs	细胞	透明质酸衍生支架	大鼠急性和亚急性半切SCI模型
2018，Xiao等^[74]	BMMSCs	细胞	胶原蛋白支架	急性完全性SCI患者
2018，Wang等^[75]	UCMSCs	细胞	胶原蛋白支架	大鼠慢性完全性SCI模型
2018，Peng等^[76]	BMMSCs	细胞	胶原蛋白支架	大鼠急性半切SCI模型
2018，Ma等^[77]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型
2017，Yang等^[78]	BMMSCs	细胞	聚（乳酸-乙醇酸）支架	大鼠急性完全性SCI模型
2017，Li等^[79]	UCMSCs	细胞	胶原蛋白支架	犬慢性完全性SCI模型
2017，Li等^[80]	BMMSCs	细胞	透明质酸支架	大鼠急性完全性SCI模型
2016，Li等^[81]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型、犬急性半切SCI模型
2014，Zhang等^[82]	BMMSCs	细胞	明胶海绵支架	大鼠急性完全性SCI模型
2012，Cholas等^[83]	BMMSCs	细胞	胶原蛋白支架	大鼠急性半切SCI模型

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