Research progress in stem cells and their derivatives in the treatment of lower limb ischemia

doi:10.3877/cma.j.issn.2095-1221.2023.06.008

Abstract

Abstract:

Lower limb ischemia is essentially a peripheral vascular disease, and its conventional treatments include drug therapy, interventional therapy and surgery. However, for many patients, these treatments are inappropriate and they may ultimately face amputation or death. Therefore, stem cell therapy with angiogenesis, tissue regeneration and immune regulation functions provides new ideas for existing treatments. However, problems such as low cell survival rate after transplantation, poor stem cells retention at the transplant site and insufficient number of cells colonized in the recipient tissue limit the therapeutic effect and widespread application of stem cell therapy. To overcome these difficulties, the development of biomaterials and delivery systems provides new strategies. Therefore, this article reviews interventional research based on stem cell therapy, aiming to improve the effectiveness of stem cell therapy through combined means and provide new strategies for stem cell therapy for lower limb ischemia.

Key words: Lower limb ischemia, Stem cell therapy, Stem cell derivatives, Biomaterials, Delivery systems

Ruiyu Yang, Pingping Huang. Research progress in stem cells and their derivatives in the treatment of lower limb ischemia[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(06): 377-382.

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