Advances in the distribution in lung tissue and therapeutic mechanisms of mesenchymal stem cells in respiratory system diseases models

doi:10.3877/cma.j.issn.2095-1221.2024.06.008

Abstract

Abstract:

The translational research of mesenchymal stem cells （MSCs）in the treatment of respiratory system diseases has attracted widespread attention. They mainly exerts therapeutic effects through mitochondrial transfer， extracellular vesicles， and paracrine. In recent years， preclinical studies have found that MSCs migrate to lung tissues of respiratory system diseases and exhibit effective functions with repairing lung damage and inhibiting inflammation in the lung microenvironment.This review summarizes the recent progress of MSCs in the treatment of respiratory system diseases，expatiates their lung tissue distribution and therapeutic mechanism in respiratory system diseases models. This article will provide theoretical basis and strategies for the clinical research of MSCs in the treatment of respiratory system diseases.

Key words: Mesenchymal stem cells, Respiratory system diseases, Distribution of lung tissue, Therapeutic mechanism

Yuanyuan Yuan, Leqi Yue, Huaxing Zhang, Yan Wu, Quanhai Li. Advances in the distribution in lung tissue and therapeutic mechanisms of mesenchymal stem cells in respiratory system diseases models[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(06): 374-381.

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References 87

1	Hoang DM， Pham PT， Bach TQ， et al. Stem cell-based therapy for human diseases［J］. Signal Transduct Target Ther， 2022， 7（1）:272.
2	Grégoire C， Layios N， Lambermont B， et al. Bone marrow-derived mesenchymal stromal cell therapy in severe COVID-19: preliminary results of a phase I/II Clinical Trial［J］. Front Immunol， 2022， 13:932360.
3	雷耘果，姚嘉，郑俊，等.人脐带间充质干细胞来源的细胞外囊泡增强纤维化肝脏再生能力［J］.器官移植， 2023， 14（3）:379-388.
4	Møller-Hansen M， Larsen AC， Toft PB， et al. Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease［J］. Ocul Surf， 2021， 19:43-52.
5	Kim HJ， Cho KR， Jang H， et al. Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer′s disease dementia: a phase I clinical trial［J］. Alzheimers Res Ther， 2021， 13（1）:154.
6	Hashemian SR， Aliannejad R， Zarrabi M， et al. Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID- 19-induced ARDS patients: a case series［J］. Stem Cell Res Ther， 2021， 12（1）:91.
7	Held T， Herpel C， Schwindling FS， et al. 3D-printed individualized tooth-borne tissue retraction devices compared to conventional dental splints for head and neck cancer radiotherapy: a randomized controlled trial［J］. Radiat Oncol， 2021， 16（1）:75.
8	Bajek A， Olkowska J， Walentowicz-Sadłecka M， et al. High quality independent from a donor: human amniotic fluid derived stem cells-A practical analysis based on 165 clinical cases［J］. J Cell Biochem， 2017，118（1）:116-126.
9	Asgari Taei A， Khodabakhsh P， Nasoohi S， et al. Paracrine effects of mesenchymal stem cells in ischemic stroke: opportunities and challenges［J］. Mol Neurobiol， 2022， 59（10）:6281-6306.
10	Zhang L， Liu Q， Hu H， et al. Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease［J］. Biomed Pharmacother， 2022， 153:113482.
11	Lin Z， Wu Y， Xu Y， et al. Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential［J］.Mol Cancer， 2022， 21（1）:179.
12	L PK， Kandoi S， Misra R， et al. The mesenchymal stem cell secretome:A new paradigm towards cell-free therapeutic mode in regenerative medicine［J］. Cytokine Growth Factor Rev， 2019， 46:1-9.
13	Krampera M， Le Blanc K. Mesenchymal stromal cells:putative microenvironmental modulators become cell therapy［J］. Cell Stem Cell， 2021， 28（10）:1708-1725.
14	Lan T， Luo M， Wei X. Mesenchymal stem/stromal cells in cancer therapy［J］. J Hematol Oncol， 2021， 14（1）:195.
15	Pan Y， Wu W， Jiang X， et al. Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy［J］. Biomed Pharmacother， 2023， 163:114817.
16	Shi M， Li YY， Xu RN， et al. Mesenchymal stem cell therapy in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized controlled clinical trial［J］. Hepatol Int， 2021， 15（6）:1431-1441.
17	Izadi M， Sadr Hashemi Nejad A， Moazenchi M， et al. Mesenchymal stem cell transplantation in newly diagnosed type-1 diabetes patients: a phase Ⅰ/Ⅱ randomized placebo-controlled clinical trial［J］. Stem Cell Res Ther， 2022， 13（1）:264.
18	Monsel A， Hauw-Berlemont C， Mebarki M， et al. Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial［J］. Crit Care， 2022， 26（1）:48.
19	Zheng W， Li H， Hu K， et al. Chondromalacia patellae: current options and emerging cell therapies［J］. Stem Cell Res Ther， 2021， 12（1）:412.
20	Chung JW， Chang WH， Bang OY， et al. Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke［J］. Neurology，2021， 96（7）:e1012-e1023.
21	Wang L， Zhang Z， Xu R， et al. Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial［J］. Signal Transduct Target Ther， 2021， 6（1）:217.
22	Zhao K， Lin R， Fan Z， et al. Mesenchymal stromal cells plus basiliximab， calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter， randomized， phase 3，open- label trial［J］. J Hematol Oncol， 2022， 15（1）:22.
23	Squillaro T， Peluso G， Galderisi U. Clinical trials with mesenchymal stem cells: an update［J］. Cell Transplant， 2016， 25（5）:829-848.
24	韩立，惠利健，潘国宇.细胞的命运:间充质干细胞的药代动力学［J］.中国细胞生物学学报， 2018， 40（6）:857-866.
25	Wolfel R， Corman VM， Guggemos W， et al. MSC therapies for COVID-19: importance of patient coagulopathy， thromboprophylaxis，cell product quality and mode of delivery for treatment safety and efficacy［J］. Front Immunol，2020， 11:1091.
26	Yuan Y， Jiao B， Qu L， et al. The development of COVID-19 treatment［J］. Front Immunol， 2023， 14:1125246.
27	Chen L， Qu J， Kalyani FS， et al. Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications［J］. Cell Mol Life Sci， 2022，79（3）:142.
28	Armitage J， Tan DBA， Troedson R， et al. Mesenchymal stromal cell infusion modulates sys temic immunological responses in stable COPD patients: a phase I pilot study［J］. Eur Respir J， 2018， 51（3）:1702369.
29	Chen Q， Lv L， Zheng C， et al. Human umbilical cord-derived mesenchymal stem cells repair SU5416-injured emphysema by inhibiting apoptosis via rescuing VEGF-VEGFR2-AKT pathway in rats［J］. Int J Stem Cells， 2022，15（4）:395-404.
30	Wang X， Zhao S， Lai J， et al. Anti-inflammatory， antioxidant， and antifibrotic effects of gingival-derived MSCs on bleomycin-induced pulmonary fibrosis in mice［J］. Int J Mol Sci， 2021， 23（1）:99.
31	Gao J， Liang Y， Chen J， et al. CXCR4 enhances the inhibitory effects of bone mesenchymal stem cells on lung cell apoptosis in a rat model of smoking-induced COPD［J］. Apoptosis， 2023， 28（3-4）:639-652.
32	Xiao K， Hou F， Huang X， et al. Mesenchymal stem cells: current clinical progress in ARDS and COVID-19［J］. Stem Cell Res Ther，2020， 11（1）:305.
33	Ning K， Liu S， Yang B， et al. Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation［J］.Mol Metab， 2022， 8:101450.
34	Liu Y， Ma T. Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application［J］. Biotechnol Prog， 2015，31（2）:468-481.
35	Rybkowska P， Radoszkiewicz K， Kawalec M， et al. The metabolic changes between monolayer （2D） and three-dimensional （3D） culture conditions in human mesenchymal stem/stromal cells derived from adipose tissue［J］. Cells， 2023， 12（1）:178.
36	Liu H， Xue W， Ge G， et al. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs［J］. Biochem Biophys Res Commun， 2010， 401:509-515.
37	Mizuta Y， Akahoshi T， Guo J， et al. Exosomes from adipose tissuederived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells［J］. Stem Cell Res Ther， 2020， 11（1）:508.
38	Wang Y， Fang J， Liu B， et al. Reciprocal regulation of mesenchymal stem cells and immune responses［J］. Cell Stem Cell， 2022， 29（11）:1515-1530.
39	Yu H， Huang Y， Yang L. Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis［J］. Ageing Res Rev， 2022， 80:101684.
40	Hade MD， Suire CN， Suo Z. Mesenchymal stem cell-derived exosomes:applications in regenerative medicine［J］. Cells， 2021， 10（8）:1959.
41	Zhao Y， Yan Z， Liu Y， et al. Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application［J］. Stem Cell Res Ther， 2021，12（1）:470.
42	Sarhadi VK， Daddali R， Seppänen-Kaijansinkko R. Mesenchymal stem cells and extracellular vesicles in osteosarcoma pathogenesis and therapy［J］. Int J Mol Sci， 2021， 22（20）:11035.
43	Liu W， Rong Y， Wang J， et al. Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization［J］. J Neuroinflammation， 2020， 17（1）:47.
44	Arabpour M， Saghazadeh A， Rezaei N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cellderived exosomes［J］. Int Immunopharmacol， 2021， 97:107823.
45	Shi MM， Yang QY， Monsel A， et al. Preclinical efficacy and clinical safety of clinical-grade nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles［J］. J Extracell Vesicles，2021， 10（10）:e12134.
46	Yudintceva N， Mikhailova N， Fedorov V， et al. Mesenchymal stem cells and MSCs-derived extracellular vesicles in infectious diseases: from basic research to clinical practice［J］. Bioengineering （Basel）， 2022，9（11）:662.
47	Kirkham AM， Monaghan M， Bailey AJM， et al. Mesenchymal stem/stromal cell-based therapies for COVID-19: First iteration of a living systematic review and meta-analysis: MSCs and COVID-19［J］.Cytotherapy， 2022， 24（6）:639-649.
48	Lee DK， Song SU. Immunomodulatory mechanisms of mesenchymal stem cells and their therapeutic applications［J］. Cell Immunol， 2018，326:68-76.
49	Chen J， Zhang X， Xie J， et al. Overexpression of TGFβ1 in murine mesenchymal stem cells improves lung inflammation by impacting the Th17/Treg balance in LPS-induced ARDS mice［J］. Stem Cell Res Ther，2020， 11（1）:311.
50	Yan W， Diao S， Fan Z. The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells［J］. Stem Cell Res Ther， 2021， 12（1）:140.
51	Wei B， Ji M， Lin Y， et al. Mitochondrial transfer from bone mesenchymal stem cells protects against tendinopathy both in vitro and in vivo［J］. Stem Cell Res Ther， 2023， 14（1）:104.
52	Xia L， Zhang C， Lv N， et al. AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages［J］. Theranostics， 2022，12（6）:2928-2947.
53	Dutra Silva J， Su Y， Calfee CS， et al. Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS［J］. Eur Respir J，2021， 58（1）:2002978.
54	Meftahi GH， Jangravi Z， Sahraei H， er al. The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging" ［J］. Inflamm Res， 2020，69（9）:825-839.
55	Leng Z， Zhu R， Hou W， et al. Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia［J］. Aging Dis， 2020， 11（2）:216-228.
56	Nobari S， Rezvan M， Dashtestani F， et al. Cellular therapy: the hope for Covid-19［J］. Avicenna J Med Biotechnol， 2022， 14（2）:104-113.
57	Fernández-Francos S， Eiro N， González-Galiano N， et al. Mesenchymal stem cell-based therapy as an alternative to the treatment of acute respiratory distress syndrome: current evidence and future perspectives［J］. Int J Mol Sci， 2021， 22（15）:7850.
58	Liu P， Yang S， Shao X， et al. Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis［J］. Stem Cells Transl Med， 2024， 13（4）:371-386.
59	Xiao K， He W， Guan W， et al. Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury［J］. Cell Death Dis， 2020，11（10）:863.
60	Chu M， Wang H， Bian L， et al. Nebulization therapy with umbilical cord mesenchymal stem cell-derived exosomes for COVID-19 pneumonia［J］. Stem Cell Rev Rep， 2022， 18（6）:2152-2163.
61	Zarrabi M， Shahrbaf MA， Nouri M， et al. Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID-19 induced ARDS: a randomized controlled trial［J］. Stem Cell Res Ther， 2023，14（1）:169.
62	Liu X， Gao C， Wang Y， et al. BMSC-derived exosomes ameliorate LPS-induced acute lung injury by miR-384-5p-controlled alveolar macrophage autophagy［J］. Oxid Med Cell Longev， 2021:9973457.
63	Savin IA， Zenkova MA， Sen′kova AV. Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms， relevant invivomodels， prognostic and therapeutic approaches［J］. Int J Mol Sci，2022， 23（23）:14959.
64	Cheng W， Zeng Y， Wang D. Stem cell-based therapy for pulmonary fibrosis［J］. Stem Cell Res Ther， 2022， 13（1）:492.
65	Bao H， Cheng S， Li X， et al. Functional Au nanoparticles for engineering and long-term CT imaging tracking of mesenchymal stem cells in idiopathic pulmonary fibrosis treatment［J］. Biomaterials， 2022，288:121731.
66	Huang J， Huang J， Ning X， et al. CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis［J］. J Mater Chem B， 2020， 8（8）:1713-1727.
67	Xia Y， Bao H， Huang J， et al. Near-infrared-persistent luminescence/bioluminescence imaging tracking of transplanted mesenchymal stem cells in pulmonary fibrosis［J］. Biomater Sci， 2020， 8（11）:3095-3105.
68	Zhao Y， Du L， Sun J， et al. Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis［J］. Cell Biol Toxicol， 2023， 39（6）:2919-2936.
69	Abbaszadeh H， Ghorbani F， Abbaspour-Aghdam S， et al. Chronic obstructive pulmonary disease and asthma: mesenchymal stem cells and their extracellular vesicles as potential therapeutic tools［J］. Stem Cell Res Ther， 2022， 13（1）:262.
70	Kim YS， Kim JY， Shin DM， et al. Tracking intravenous adipose-derived mesenchymal stem cells in a model of elastase-induced emphysema［J］.Tuberc Respir Dis （Seoul）， 2014， 77（3）:116-123.
71	金志贤，王清，毕虹，等. 间充质干细胞移植对大鼠肺气肿的疗效及其可能机制［J］.中华医学杂志， 2015， 95（22）:1731-1735.
72	吴华拉，周湘乡，钟玉兰等.碱性成纤维细胞生长因子转染骨髓间充质干细胞移植治疗慢性阻塞性肺疾病的作用及机制［J］.中国组织工程研究， 2019， 23（21）:3378-3385.
73	何桦，赵祝香，张颖.骨髓间充质干细胞移植在肺气肿大鼠模型肺组织内定植研究［J］.中国医学创新， 2014， 11（21）:26-30.
74	赵晓建，卢彩平，褚伟伟等.间充质干细胞归巢到大鼠肺气肿组织分化为肺血管内皮细胞［J］.中国组织工程研究， 2017， 21（29）:4728-4733.
75	Mohammadian M， Sadeghipour HR， Jahromi GP， et al. Simvastatin and bone marrow-derived mesenchymal stem cells （BMSCs） affects serum IgE and lung cytokines levels in sensitized mice［J］. Cytokine， 2019，113:83-88.
76	Meyer NJ， Gattinoni L， Calfee CS. Acute respiratory distress syndrome［J］. Lancet， 2021， 398（10300）:622-637.
77	Dos Santos CC， Amatullah H， Vaswani CM， et al. Mesenchymal stromal （stem） cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury［J］. Eur Respir J， 2022，59（1）:2004216.
78	Li L， Dong L， Zhang J， et al. Mesenchymal stem cells with downregulated Hippo signaling attenuate lung injury in mice with lipopolysaccharide induced acute respiratory distress syndrome［J］. Int J Mol Med， 2019， 43（3）:1241-1252.
79	Zhang X， Chen J， Xue M， et al. Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice［J］. Stem Cell Res Ther，2019， 10（1）:74.
80	Cai SX， Liu AR， Chen S， et al. Activation of Wnt/β-catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice［J］. Stem Cell Res Ther， 2015，6（1）:65.
81	Cui P， Xin H， Yao Y， et al. Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats［J］.Stem Cell Res Ther， 2018， 9（1）:101.
82	Zhang S， Jiang W， Ma L， et al. Nrf2 transfection enhances the efficacy of human amniotic mesenchymal stem cells to repair lung injury induced by lipopolysaccharide［J］. J Cell Biochem， 2018， 119（2）:1627-1636.
83	Liu J， Li P， Zhu J， et al. Mesenchymal stem cell-mediated immunomodulation of recruited mononuclear phagocytes during acute lung injury: a high-dimensional analysis study［J］. Theranostics， 2021，11（5）:2232-2246.
84	Peng W， Chang M， Wu Y， et al. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway［J］. Stem Cell Res Ther， 2021， 12（1）:216.
85	Liu G， Lv H， An Y， et al. Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury［J］. Int J Mol Med， 2018，41（5）:2527-2534.
86	Xiang B， Chen L， Wang X， et al. Transplantation of menstrual bloodderived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury［J］. Int J Mol Sci， 2017， 18（4）:689.
87	Liu L， He H， Liu A， et al. Therapeutic effects of bone marrow-derived mesenchymal stem cells in models of pulmonary and extrapulmonary acute lung injury［J］. Cell Transplant， 2015， 24（12）:2629-2642.

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