Regulatory T cells in tissue repair and regeneration

doi:10.3877/cma.j.issn.2095-1221.2024.01.008

Abstract

Abstract:

The immune response to tissue injury is pivotal in determining the speed and the outcome of the healing process. Modulation of the immune response through biomaterials and drug delivery systems for the regeneration of tissue repair is emerging as a promising alternative in tissue engineering and regenerative medicine. Therefore, elucidating the exact functions of different immune components in the process of tissue repair and regeneration is essential for designing efficient regenerative strategies. The adaptive immune system, especially regulatory T cells (Tregs) , has been shown to promote the repair and regeneration of various tissues and organs. This review outlines the underlying immune mechanisms of Tregs involved in tissue repair and regeneration and summarizes the key roles of Tregs during the repair and regeneration of various tissues and organs such as skin and myocardium. The practical applications of Tregs in tissue engineering and regenerative medicine are also introduced.

Key words: Regulatory T cells, Adaptive immunity, Tissue regeneration, Regenerative medicine

Mingting Zhao, Guo Zhang, Jiaming Sun. Regulatory T cells in tissue repair and regeneration[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(01): 51-55.

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References 44

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特异性组织	修复再生作用	具体效能分子	参考文献
血管	促进内皮细胞增殖及功能化	IL-1、AREG	[20]
皮肤	促进毛囊干细胞的增殖与分化	Notch配体Jag1	[18]
	促进伤口上皮化及闭合	EGFR，抑制IFN-γ产生	[21]
骨骼肌	加速骨骼肌修复	AREG、TGF-β及IL-10	[22]
	缓解炎症及减轻纤维化	抑制NK细胞及T细胞的IFN-γ表达	[23]
	改善肌营养不良、促进肌肉再生	TCR	[24]
肠道	促进肠道上皮干细胞的更新	IL-10	[25]
肝脏	改善对乙酰氨基酚诱导肝损伤	IL-10、TGF-β	[26]
肺泡	促进II型肺泡上皮细胞增殖	CD103	[27]
		KGF	[28]
	保护肺上皮感染后进一步受损	AREG	[29]
心肌	增加胶原蛋白含量、促进梗塞区成熟	Sparc	[30]
	促进心肌细胞增殖	CCL24、GAS6及AREG	[31]
		CST7、TNFSF11、IL-33、FGL2、MATN2、IGF2	[32]
中枢神经系统	抑制神经毒性星形胶质细胞形成	AREG，抑制IL-6信号通路减少星形胶质细胞的形成	[33]
	促进少突胶质祖细胞分化及再髓鞘化	CCN3蛋白	[17]

特异性组织	修复再生作用	具体效能分子	参考文献
血管	促进内皮细胞增殖及功能化	IL-1、AREG	[20]
皮肤	促进毛囊干细胞的增殖与分化	Notch配体Jag1	[18]
	促进伤口上皮化及闭合	EGFR，抑制IFN-γ产生	[21]
骨骼肌	加速骨骼肌修复	AREG、TGF-β及IL-10	[22]
	缓解炎症及减轻纤维化	抑制NK细胞及T细胞的IFN-γ表达	[23]
	改善肌营养不良、促进肌肉再生	TCR	[24]
肠道	促进肠道上皮干细胞的更新	IL-10	[25]
肝脏	改善对乙酰氨基酚诱导肝损伤	IL-10、TGF-β	[26]
肺泡	促进II型肺泡上皮细胞增殖	CD103	[27]
		KGF	[28]
	保护肺上皮感染后进一步受损	AREG	[29]
心肌	增加胶原蛋白含量、促进梗塞区成熟	Sparc	[30]
	促进心肌细胞增殖	CCL24、GAS6及AREG	[31]
		CST7、TNFSF11、IL-33、FGL2、MATN2、IGF2	[32]
中枢神经系统	抑制神经毒性星形胶质细胞形成	AREG，抑制IL-6信号通路减少星形胶质细胞的形成	[33]
	促进少突胶质祖细胞分化及再髓鞘化	CCN3蛋白	[17]

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