The role of non-coding RNAs in regulating of endothelial progenitor cells in venous thrombosis

doi:10.3877/cma.j.issn.2095-1221.2022.03.008

Abstract

Abstract:

Venous thromboemlism (VTE) , which includes deep vein thrombosis (DVT) and pulmonary embolism (PE) , is the third most common vascular disease in the world and poses serious threat to patients' lives. Currently, the clinical treatment of DVT is not very effective. Studies have found that circulating endothelial progenitor cells play an important role in the resolution and recanalization of DVT, however, the unfavorable microenvironment reduced the function. Non-coding RNAs, especially long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) , play an important role in improving the biological functions of endothelial progenitor cells. They can use as biological markers and therapeutic targets for clinical diseases. Studies have also found that non-coding RNAs regulated the function of endothelial progenitor cells in the occurrence and development of VTE and the molecular mechanisms, which may provide new methods for the prevention and treatment of VTE in clinic, and give hope to VTE patients. Here, we mainly review the characteristics of VTE, the regulation of endothelial progenitor cells on venous thrombosis, and the effects of non-coding RNAs on endothelial progenitor cells on venous thrombosis, which provides a certain reference value and theoretical basis for the diagnosis, prevention, treatment and prognosis of VTE.

Key words: lncRNAs, Endothelial progenitor cell, Venous thromboembolism, Deep vein thrombosis, Regenerative medicine

Lili Sun, Xiaoqiang Li, Ming Zhang, Jian Zhu, Dian Huang. The role of non-coding RNAs in regulating of endothelial progenitor cells in venous thrombosis[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(03): 181-185.

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