Research progress and challenges of differentiation of pluripotent stem cells into kidney organoids

doi:10.3877/cma.j.issn.2095-1221.2021.01.009

Abstract

Abstract:

In biology, in vitro culture of pluripotent stem cells has been widely used to differentiate into various types of cells. Kidney organs derived from pluripotent stem cells can basically restore the tissue structure and partial function of kidney. It plays an important role in the research of kidney disease model and drug screening, and helps to improve the structure, function and maturity of kidney like organs, and is helpful to the treatment of kidney regeneration. Accurate simulation of kidney development in vitro is the focus in kidney organ research. The key point in kidney organoids study is to accurately simulate the development process of kidney in vitro. In this review, we summarize, analyze, and compare key points for kidney organoid differentiation techniques with focus on the process of embryonic kidney development over the past decade, and discuss the challenges for kidney organoids in differentiation research and applications.

Key words: Pluripotent stem cell, Kidney, Organoid, Kidney development, Regenerative medicine

Yilin Liu, Zhipeng Wu, Jiang Qiu. Research progress and challenges of differentiation of pluripotent stem cells into kidney organoids[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(01): 57-62.

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