The role of immune cells in renal ischemia-reperfusion injury and repair

doi:10.3877/cma.j.issn.2095-1221.2024.01.007

Abstract

Abstract:

Acute kidney injury (AKI) is a common clinical syndrome. The total incidence of AKI in hospitalized population in China is as high as 11.6%, and the occurrence of AKI is easy to progress to chronic kidney disease (CKD) and even end-stage renal disease (ESRD) . Ischemia-reperfusion injury (IRI) is one of the major causes of AKI. Renal tubular epithelial cells are the main cell types damaged in the process of IRI induced AKI, and also the main cell source of cell regeneration in the process of kidney repair. During the development and repair of AKI, immune cells regulate the damage, proliferation and re-epithelialization of renal tubular epithelial cells and other biological processes, which eventually lead to different outcomes of AKI. In this paper, the role of immune cells in the process of AKI induced by IRI and the challenges and developments in the field are reviewed.

Key words: Acute kidney injury, Immune cells, Renal ischemia/reperfusion, Renal injury and repair

Shouqing Cao, Dong Lai, Qilong Jiao, Zhekun An, Xiubin Li. The role of immune cells in renal ischemia-reperfusion injury and repair[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(01): 45-50.

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