Research progress of stem cell therapy in polycystic ovary syndrome

doi:10.3877/cma.j.issn.2095-1221.2023.02.007

Abstract

Abstract:

Stem cell based therapy is rapidly developing and widely applied in medical field. Several reproductive diseases have been treated using various types of stem cells in experimental studies and clinical trials, which have produced favorable results. In recent years, some experimental research progress of mesenchymal stem cells (MSCs) derived from different sources in the treatment of polycystic ovary syndrome (PCOS) has been reported. This article reviewed the mechanism of MSCs and their exosomes in the treatment of PCOS, including regulating hormones, sugar and lipid metabolism, inhibiting inflammatory response, regulating immune function, homing effect, promoting angiogenesis, and enhancing ovulation and reproductive potential function. This review also summarized the progress of experimental research on induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) in PCOS and provided some exploration ideas for the clinical research and application of stem cells in PCOS.

Key words: Polycystic ovary syndrome, Mesenchymal stem cell, Exosome, Induced pluripotent stem cell, Embryonic stem cell

Wanmeng Fu, Xiaoli Wang, Yu Liu, Wei Zhang, Ju Zhang. Research progress of stem cell therapy in polycystic ovary syndrome[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(02): 108-114.

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