Correlation of pluripotency of embryonic stem cells with DNA methylation

doi:10.3877/cma.j.issn.2095-1221.2019.03.010

Abstract

Abstract:

Embryonic Stem cells is a kind of pluripotent stem cells which can maintain self-renewal and have unlimited expansion ability. Primate pluripotent stem cells (PSCs) are defined as naive- and primed- state according to their varieties in cellular, molecular, epigenetic and functional states. nPSCs had attracted much attention in clinical application because of its easy for genetic engineering and regeneration of functional tissues and organs in vitro or in vivo. Thus maintaining their na?ve state effectively is of great significance to basic and clinical research of stem cells. Numerous studies shows that na?ve PSCs had a higher mitochondrial activity and self-?renewal ability than Primed ESCs, and there were significant differences between these two kinds of pluripotent stem cellsin DNA methylation. This article provides the effect of DNA methylation on embryonic stem cells, particularly focusing on the maintenance of embryonic stem cell naive state.

Key words: DNA methylation, Pluripotent stem cells, Embryonic stem cells

Ruofeng Wang, Yonghong Guo, Qin Tian, Weige Duan. Correlation of pluripotency of embryonic stem cells with DNA methylation[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(03): 188-192.

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