Applications and development of induced-pluripotent-stem-cell-derived hematopoietic cells in hematological diseases

doi:10.3877/cma.j.issn.2095-1221.2018.05.009

Abstract

Abstract:

Bone marrow (BM) transplantation has been successfully used in many hematological diseases for several years, which mainly depends on hematopoietic stem cells (HSCs) from adult BM and peripheral blood (PB). However, the rarity of HSCs with appropriate matching has limited their applications to patients. Fortunately, the advent of iPSCs, which have the potential to differentiate into all cell types of the hematopoietic system, makes the wide applications of HSCs and other blood cells in hematology possible. However, there are still many barriers in using iPSCs in treating hematological diseases. This article mainly reviews the applications, development and some unsolved issues and challenges of iPSCs in hematology.

Key words: Induced pluripotent stem cells, Hematopoietic disease, Disease modeling, Therapeutic transfusion

Lei Gu, Jing Lin, Yongchun Wang, Wei Liu, Wen Wen, Guoxiang Lai, Deling Liu, Yuebin Liu, Jin Chen, Zhong Yang. Applications and development of induced-pluripotent-stem-cell-derived hematopoietic cells in hematological diseases[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(05): 310-314.

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References 54

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