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Chinese Journal of Cell and Stem Cell(Electronic Edition) ›› 2018, Vol. 08 ›› Issue (05): 303-309. doi: 10.3877/cma.j.issn.2095-1221.2018.05.008

Special Issue:

• Review • Previous Articles     Next Articles

CAR-NK immunotherapy for tumor: pre-clinical and clinical research

Bing Liu1, Meiling Zhou1, Tao Liu1,()   

  1. 1. Department of Biotherapy and Oncology, Shenzhen Luohu People's Hospital, the 3rd Affiliated Hospital of Shenzhen University, Shenzhen 518001, China
  • Received:2018-08-03 Online:2018-10-01 Published:2018-10-01
  • Contact: Tao Liu
  • About author:
    Corresponding author:Liu Tao, Email:

Abstract:

Cancer immunotherapy attracts great attention in recent years. Chimeric antigen receptor (CAR) engineered T cell immunotherapy is effective for hematologic malignancies with reliable clinical results. Natural killer cells (NK) is one kind of important innate immune cells which have advantages in the treatment of solid tumor. Both in vitro and in mouse models, CAR-NK have shown encouraging antitumor effects. Current clinical trials show that CAR-NK cells have great therapeutic potential for hematologic malignancies. Although there are bottlenecks that need to be overcome for CAR-NK to treat solid tumors, the future of CAR-NK cells is promising.

Key words: Chimeric antigen receptor, CAR-NK, Hematologic tumor, Solid tumor, Tumor cytotherapy

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