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中华细胞与干细胞杂志(电子版) ›› 2026, Vol. 16 ›› Issue (01) : 39 -44. doi: 10.3877/cma.j.issn.2095-1221.2026.01.005

综述

造血干细胞衰老的分子机制与干预策略
武文1, 周振宇2,()   
  1. 1250031 济南,中国人民解放军联勤保障部队第九六〇医院输血医学科
    2250031 济南,中国人民解放军联勤保障部队第九六〇医院骨科
  • 收稿日期:2025-10-22 出版日期:2026-02-01
  • 通信作者: 周振宇
  • 基金资助:
    济南市临床医学科技创新计划(202225066)

Molecular mechanisms and interventional strategies of hematopoietic stem cell aging

Wen Wu1, Zhenyu Zhou2,()   

  1. 1Department of Transfusion Medicine, the 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China
    2Department of Orthopedics, the 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China
  • Received:2025-10-22 Published:2026-02-01
  • Corresponding author: Zhenyu Zhou
引用本文:

武文, 周振宇. 造血干细胞衰老的分子机制与干预策略[J/OL]. 中华细胞与干细胞杂志(电子版), 2026, 16(01): 39-44.

Wen Wu, Zhenyu Zhou. Molecular mechanisms and interventional strategies of hematopoietic stem cell aging[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2026, 16(01): 39-44.

造血干细胞(HSCs)衰老是细胞内在衰老程序与造血微环境改变共同作用的结果,其特征表现为自我更新能力衰退、髓系分化偏向、归巢定植缺陷及克隆多样性降低等,HSCs功能减退增加恶性血液病及多种衰老相关疾病发病风险。单细胞转录组测序、表观遗传学图谱与基因编辑技术从基因损伤、表观遗传学改变及造血微环境变化等方面系统阐释HSCs衰老的核心机制,同时提出多种HSCs年轻化策略。本文系统综述HSCs衰老研究进展,明确HSCs衰老的关键调控点与干预靶点,旨在为延缓HSCs衰老及治疗相关疾病提供理论依据。

The aging of hematopoietic stem cells (HSCs) is the result of the combined effects of intrinsic cellular senescence programs and changes in the hematopoietic microenvironment, which is characterized by diminished self-renewal capacity, myeloid differentiation bias, homing and colonization defects, and the reduction of clonal diversity, etc. These functional declines significantly increase the risk of malignant blood disorders and various aging-related diseases. The application of technologies such as single-cell RNA sequencing, epigenomic mapping, and gene editing has not only elucidated the core mechanisms of HSCs aging such as gene damage, epigenetic alterations and changes in the hematopoietic microenvironment, but also led to the proposal of multiple strategies for HSCs rejuvenation. This review systematically summarizes recent advances in HSCs aging research, aiming to identify key regulatory nodes and potential intervention targets, providing a solid theoretical foundation and technical prospects for the prevention and treatment of related aging diseases.

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