Progress in histone deacetylase inhibitor regulation of stem cell differentiation and somatic reprogramming

doi:10.3877/cma.j.issn.2095-1221.2020.02.008

Abstract

Abstract:

Epigenetic regulation, such as histone acetylation, is an important mechanism that determines the direction of stem cell differentiation. Histone deacetylase inhibitors (HDACi) affect the histone deacetylase (HDAC) activity in different subclasses, increase the level of histone acetylation and regulate gene expression, thus, the self-renewal of embryonic stem cell (ESC) and the directional differentiation of ESC along the cell lines of neurons, myocardium and hematopoietic cells were affected. HDACi-like small molecules are also widely used in somatic cell reprogramming, which can replace c-Myc and Klf4 and promote somatic cell cloning. Studies have shown that the effect of HDACi is closely related to drug dose, cell type and cell differentiation. This review focuses on the application of HDACi in stem cell differentiation and reprogramming, and moreover discusses the molecular pathways involved, which can help to reveal the key molecular mechanism of directional differentiation and optimize the induction strategy of directional differentiation of stem cells, it is of great value to the induction and differentiation of stem cells.

Key words: HDAC inhibitor, Stem cell, Cell differentiation, Reprogramming

Zezhao He, Xiaofei Weng. Progress in histone deacetylase inhibitor regulation of stem cell differentiation and somatic reprogramming[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(02): 115-118.

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