Application and prospect of mesenchymal stem cells in treatment of inflammatory bowel disease

doi:10.3877/cma.j.issn.2095-1221.2019.04.008

Abstract

Abstract:

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, with unknown aetiology. There is a tendency to relapse throughout the life of patients with IBD and the severe cases cannot be cured. Early treatment is based on drugs, and some severe patients require surgical intervention later. In recent years, mesenchymal stem cells (MSCs) have been widely used in the experimental research of IBD treatment due to their multi-directional differentiation potential, immune regulation and tissue repair function, and it has a certain theoretical basis. In some clinical trials of MSCs for the treatment of IBD, there no serious complications have been reported and a certain therapeutic effect has been found. Currently, such stem cell therapy is not a standard of treatment regimen for IBD. However, it may potentially become a new option, especially for the IBD which is refractory or complicated with anal fistula. The purpose of this review article is to summarize the basic characteristics of MSCs, demonstrate the mechanism and application of MSCs in the therapy of IBD and prospect its trend in the future.

Key words: Mesenchymal stem cells, Inflammatory bowel disease, Mechanism, Prospects

Xianzhe Li, Minghao Xie, Lei Lian. Application and prospect of mesenchymal stem cells in treatment of inflammatory bowel disease[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(04): 236-241.

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