Umbilical cord blood stem cell transplantation for non-malignant hematological diseases

doi:10.3877/cma.j.issn.2095-1221.2019.04.009

Abstract

Abstract:

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to cure non-malignant hematological diseases. Umbilical cord blood stem cells (UCB) are characterized by weak immunogenicity, good tolerance human leukocyte antigen (HLA) mismatch, low incidence of graft-versus-host disease and relatively fast availability. UCB can be used as the graft of allo-HSCT for patients with non-malignant hematological diseases. This article reviews the efficacy of the umbilical cord blood stem cell transplantation (UCBT) in patients with primary immunodeficiency, hereditary bone marrow failure, hereditary metabolic diseases and autoimmune diseases.

Key words: Umbilical cord blood, Stem cells, Transplantation, Non-malignant diseases

Ping Wang, Xiaowen Zhai. Umbilical cord blood stem cell transplantation for non-malignant hematological diseases[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(04): 242-246.

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URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2019.04.009

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References 41

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UCBT治疗疾病类型		预处理方案	总体生存率	参考文献
PIDs	SCID	无/减低强度预处理/清髓性预处理	58﹪~ 73﹪	[4,5,6,7]
?	CGD	减低强度预处理/清髓性预处理	100﹪	[7,10,12,13]
?	WAS	减低强度预处理/清髓性预处理	82﹪	[7]
IBMF	FA	减低强度预处理	40﹪	[22]
IEM	MPS	清髓性预处理	77﹪~ 95﹪	[28,29]
?	ALD	清髓性预处理	59﹪~ 69﹪	[32,33]
?	GLD	清髓性预处理	43﹪~100﹪	[32,33,36]
VEO-IBD	?	尚无UCBT大样本报道	?	?

UCBT治疗疾病类型		预处理方案	总体生存率	参考文献
PIDs	SCID	无/减低强度预处理/清髓性预处理	58﹪~ 73﹪	[4,5,6,7]
?	CGD	减低强度预处理/清髓性预处理	100﹪	[7,10,12,13]
?	WAS	减低强度预处理/清髓性预处理	82﹪	[7]
IBMF	FA	减低强度预处理	40﹪	[22]
IEM	MPS	清髓性预处理	77﹪~ 95﹪	[28,29]
?	ALD	清髓性预处理	59﹪~ 69﹪	[32,33]
?	GLD	清髓性预处理	43﹪~100﹪	[32,33,36]
VEO-IBD	?	尚无UCBT大样本报道	?	?

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