Current opinions on malignant transformation of mesenchymal stem cell

doi:10.3877/cma.j.issn.2095-1221.2017.04.008

Abstract

Abstract:

Mesenchymal stromal (stem) cells (MSCs) are pluripotent stem cells to differentiate into various types of cells. This unique characteristic allowed MSCs to be used in cytotherapy, which holds most promising for repair of injured cells/tissues and anti-tumor intervention. However, malignant transformation of MSCs is a major challenge for clinical applications. This review focuses on the recent studies regarding culture conditions, molecular mechanisms, and preventive strategies of malignance of MSCs in practice.

Key words: Mesenchymal stem cell, Cell transformation, neoplastic

Cong Liu, Mo Zhang, Hong-Long Ji. Current opinions on malignant transformation of mesenchymal stem cell[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(04): 231-236.

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References 78

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机理类型	细胞类型	相关基因	肿瘤类型
癌相关基因表达异常	hMSCs	c-myc＃，Rb*	骨肉瘤
?	小鼠MSCs	p21－，p53－	纤维肉瘤
?	p53KOMSCs	c-myc＃，K-RasG12V＃，Pten－	未知
?	小鼠BMMSCs	c-myc＃，p16INK4a－/p19ARF－	骨肉瘤
?	小鼠MSCs	Cdkn2－/p16INK4a－	骨肉瘤
?	小鼠MSCs	IDH2突变	肉瘤
细胞因子	IL-6诱导大鼠MSCs	STAT3↑	未知
细胞信号通路异常	小鼠BMMSCs	Notch↑，Hedgehog↓，Wnt↓	肉瘤
染色体突变	人BMMSCs	高端粒酶活性，染色体易位，非整倍体	实体瘤
?	小鼠BMMSCs	染色体变异＃	肉瘤

机理类型	细胞类型	相关基因	肿瘤类型
癌相关基因表达异常	hMSCs	c-myc＃，Rb*	骨肉瘤
?	小鼠MSCs	p21－，p53－	纤维肉瘤
?	p53KOMSCs	c-myc＃，K-RasG12V＃，Pten－	未知
?	小鼠BMMSCs	c-myc＃，p16INK4a－/p19ARF－	骨肉瘤
?	小鼠MSCs	Cdkn2－/p16INK4a－	骨肉瘤
?	小鼠MSCs	IDH2突变	肉瘤
细胞因子	IL-6诱导大鼠MSCs	STAT3↑	未知
细胞信号通路异常	小鼠BMMSCs	Notch↑，Hedgehog↓，Wnt↓	肉瘤
染色体突变	人BMMSCs	高端粒酶活性，染色体易位，非整倍体	实体瘤
?	小鼠BMMSCs	染色体变异＃	肉瘤

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