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中华细胞与干细胞杂志(电子版) ›› 2026, Vol. 16 ›› Issue (01) : 52 -55. doi: 10.3877/cma.j.issn.2095-1221.2026.01.007

综述

干细胞:开启精神疾病治疗的新曙光
徐倩1, 魏凤香1,2,()   
  1. 1230001 合肥,安徽医科大学公共卫生学院
    2518100 深圳,深圳市龙岗区妇幼保健院[汕头大学医学院附属深圳妇儿医院 (龙岗)]干细胞与再生医学研究中心
  • 收稿日期:2025-04-02 出版日期:2026-02-01
  • 通信作者: 魏凤香
  • 基金资助:
    深圳市科创委(JCYJ20240813144059046)

Stem cells: a new dawn for treating psychiatric disorders

Qian Xu1, Fengxiang Wei1,2,()   

  1. 1School of Public Health, Anhui Medical University, Hefei 230001, China
    2Stem Cell and Regenerative Medicine Research Center, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College) , Shenzhen 518100, China
  • Received:2025-04-02 Published:2026-02-01
  • Corresponding author: Fengxiang Wei
引用本文:

徐倩, 魏凤香. 干细胞:开启精神疾病治疗的新曙光[J/OL]. 中华细胞与干细胞杂志(电子版), 2026, 16(01): 52-55.

Qian Xu, Fengxiang Wei. Stem cells: a new dawn for treating psychiatric disorders[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2026, 16(01): 52-55.

精神疾病是一类患病率高、治疗复杂的疾病,传统的药物治疗常伴随着代谢方面的副作用,而心理干预在疗效上又存在不足,这些局限使针对精神疾病创新疗法的需求愈发迫切。干细胞因具备自我更新、多向分化以及旁分泌调节等特点,为多种疾病的治疗开辟了全新策略。本综述主要针对干细胞在精神分裂症、抑郁症和孤独症这3种常见精神疾病治疗中的应用进行概括,剖析其作用机制并系统总结当前研究进展,旨在全面梳理现状,为精神疾病治疗方案的优化提供依据。

Psychiatric disorders are a class of diseases with a high prevalence and complex treatment. Traditional drug treatments are often accompanied by metabolic side effects, while psychological interventions are clearly ineffective in terms of efficacy, which make the need for innovative treatments for psychiatric disorders even more urgent. Due to the characteristics of self-renewal, multi-directional differentiation and paracrine regulation, stem cells have opened up new strategies for the treatment of a variety of diseases. This review summarizes the stem cell applications and mechanisms in schizophrenia, depression, and autism, further highlights current clinical progress to inform optimization of future therapeutic strategies.

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