| 1 |
Shen Y, Li X, Yao J. Develop a clinical prediction model for postoperative cognitive dysfunction after major noncardiac surgery in elderly patients: a protocol for a prospective observational study[J]. Gerontology, 2022, 68(5):538-545.
|
| 2 |
Liang Y, Xin X, Wang H, et al. A novel predictive strategy for the incidence of postoperative neurocognitive dysfunction in elderly patients with mild cognitive impairment[J]. Front Aging Neurosci, 2022, 14:985406.
|
| 3 |
任世广, 王丹丹, 胡睿, 等. 老年胃肠肿瘤患者术后认知功能障碍危险因素的研究进展[J]. 中国医学创新, 2025, 22(29):179-184.
|
| 4 |
ávila-Gómez P, Shingai Y, Dash S, et al. Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction[J]. eNeuro 2024, 11(9).
|
| 5 |
He K, Zhang J, Zhang W, et al. Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders[J]. Front Aging Neurosci, 2022, 14:772066.
|
| 6 |
van Loo G, Bertrand MJM. Death by TNF: a road to inflammation[J]. Nat Rev Immunol, 2023, 23(5):289-303.
|
| 7 |
Woodburn SC, Bollinger JL, Wohleb ES. The semantics of microglia activation: neuroinflammation, homeostasis, and stress[J]. J Neuroinflammation, 2021, 18(1):258.
|
| 8 |
Dong J, Tong W, Liu M, et al. Endosomal traffic disorders: a driving force behind neurodegenerative diseases[J]. Transl Neurodegener, 2024, 13(1):66.
|
| 9 |
Lu T, Ma L, Xu Q, et al. Blood Th17 cells and IL-17A as candidate biomarkers estimating the progression of cognitive impairment in stroke patients[J]. J Clin Lab Anal, 2022, 36(8):e24581.
|
| 10 |
Martins de Carvalho L, Chen WY, and Lasek AW. Epigenetic mechanisms underlying stress-induced depression[J]. Int Rev Neurobiol, 2021, 156:87-126.
|
| 11 |
Garro-Martínez E, Fullana MN, Florensa-Zanuy E, et al. mTOR knockdown in the infralimbic cortex evokes a depressive-like state in mouse[J]. Int J Mol Sci, 2021, 22(16):8671.
|
| 12 |
Latina V, De Introna M, Caligiuri C, et al. Immunotherapy with cleavage-specific 12A12mAb reduces the tau cleavage in visual cortex and improves visuo-spatial recognition memory in Tg2576 AD mouse model[J]. Pharmaceutics, 2023, 15(2):509.
|
| 13 |
Ding Z, Liu Q, and Zhang J. SFRS8 regulates memory by modulating RNA splicing of synaptic genes[J]. Mol Neurobiol, 2025, 62(10): 12523-12538.
|
| 14 |
Chen Q, Zheng A, Xu X, et al. Nrf3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2[J]. Circulation, 2025, 151(14):1024-1046.
|
| 15 |
Han J, Kim YH, Han S. Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis[J]. Exp Mol Med, 2025, 57(2):390-401.
|
| 16 |
Wu AG, Yong YY, Pan YR, et al. Targeting Nrf2-mediated oxidative stress response in traumatic brain injury: therapeutic perspectives of phytochemicals[J]. Oxid Med Cell Longev, 2022, 2022:1015791.
|
| 17 |
Afzal M, Sidra T, and Li Y. Mitochondrial dysfunction and oxidative stress in Alzheimer's disease[J]. Front Aging Neurosci, 2021, 13:617588.
|
| 18 |
Wei C, Jiang W, Wang R, et al. Brain endothelial GSDMD activation mediates inflammatory BBB breakdown[J]. Nature, 2024, 629(8013): 893-900.
|
| 19 |
Yousef H, Czupalla CJ, Lee D, et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1[J]. Nat Med, 2019, 25(6):988-1000.
|
| 20 |
Tyrrell DJ, Blin MG, Song J, et al. Aging impairs mitochondrial function and mitophagy and elevates interleukin 6 within the cerebral vasculature[J]. J Am Heart Assoc, 2020, 9(23):e017820.
|
| 21 |
Yuki K, Hou L, Shibamura-Fujiogi M, et al. Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes[J]. Clin Immunol, 2021, 222:108635.
|
| 22 |
Goel F, Kumar D, Sharma A. Impact of corticoid receptors on Alzheimer's disease: a neuroendocrine perspective[J]. Inflammopharmacology, 2025, 33(5):2641-2656.
|
| 23 |
Samant RR, Standaert DG, Harms AS. The emerging role of disease-associated microglia in Parkinson's disease[J]. Front Cell Neurosci, 2024, 18:1476461.
|
| 24 |
Wang L, Zhao J, Zhu B, et al. Microglia polarization in heat-induced early neural injury[J]. Arch Med Sci, 2024, 20(4):1307-1313.
|
| 25 |
游丽娟, 朱紫文, 徐桂灵, 等. 胎盘间充质干细胞的免疫调节作用及机制[J]. 现代免疫学, 2025, 45(03):344-349.
|
| 26 |
Li Y, Wang F, Guo R, et al. Exosomal sphingosine 1-phosphate secreted by mesenchymal stem cells regulated Treg/Th17 balance in aplastic anemia[J]. IUBMB Life, 2019, 71(9):1284-1292.
|
| 27 |
Laing AG, Fanelli G, Ramirez-Valdez A, et al. Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress[J]. PLoS One, 2019, 14(3):e0213170.
|
| 28 |
Hu H, Li H, Li R, et al. Re-establishing immune tolerance in multiple sclerosis: focusing on novel mechanisms of mesenchymal stem cell regulation of Th17/Treg balance[J]. J Transl Med, 2024, 22(1):663.
|
| 29 |
李明芬. 骨髓间充质干细胞对CD8+ T淋巴细胞的免疫调节功能及其机制研究[D]. 广西医科大学, 2014.
|
| 30 |
Sun LH, Tian D, Yang ZC, et al. Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4[J]. Sci Rep, 2020, 10(1):8271.
|
| 31 |
Gu J, Wu J, Wang C, et al. BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury[J]. Aging (Albany NY), 2024, 16(6):5184-5206.
|
| 32 |
Qiao L, Hu S, Liu S, et al. microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential[J]. J Clin Invest, 2019, 129(6):2237-2250.
|
| 33 |
Li YX, Liu T, Liang YW, et al. Integrative analysis of long non-coding RNA and messenger RNA expression in toll-like receptor 4-primed mesenchymal stem cells of ankylosing spondylitis[J]. Ann Transl Med, 2021, 9(20):1563.
|
| 34 |
Sun XH, Wang X, Zhang Y, et al. Exosomes of bone-marrow stromal cells inhibit cardiomyocyte apoptosis under ischemic and hypoxic conditions via miR-486-5p targeting the PTEN/PI3K/AKT signaling pathway[J]. Thromb Res, 2019, 177:23-32.
|
| 35 |
Jiang L, Jones S, and Jia X. Stem cell transplantation for peripheral nerve regeneration: current options and opportunities[J]. Int J Mol Sci, 2017, 18(1):94.
|
| 36 |
Abdel Halim NY, Mohamed GH, Elhusseiny A, et al. IGF 1, BDNF, and NGF mediate the neuro-modulatory role of stem cells in acrylamide-induced hippocampal toxic changes in rats[J]. Folia Morphol (Warsz), 2024, 84(2):328-341.
|
| 37 |
Huang L, Sun X, Wang L, et al. Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice[J]. MedComm (2020), 2022, 3(3):e160.
|
| 38 |
Lech W, Kot M, Welniak-Kaminska M, et al. Dynamic changes in BDNF, VEGF, and GDNF after transplanting human protein-based scaffolds with Wharton's Jelly MSCs in a rat brain injury model[J]. Sci Rep, 2025, 15(1):22625.
|
| 39 |
Hempstead BL. Deciphering proneurotrophin actions[J]. Handb Exp Pharmacol, 2014, 220:17-32.
|
| 40 |
Hei Y, Chen R, Mao X, et al. Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion[J]. Behav Brain Res, 2019, 365:141-149.
|
| 41 |
Wu L, Cao J, Li N, et al. Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke[J]. Neuroreport, 2019, 30(9):658-663.
|
| 42 |
Tan CH, Low KA, Chiarelli AM, et al. Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging[J]. Neurobiol Aging, 2019, 84:200-207.
|
| 43 |
Ohsawa I, Nishimaki K, Murakami Y, et al. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity[J]. J Neurosci, 2008, 28(24):6239-6249.
|
| 44 |
Safar MM, Arab HH, Rizk SM, et al. Bone marrow-derived endothelial progenitor cells protect against scopolamine-induced alzheimer-like pathological aberrations[J]. Mol Neurobiol, 2016, 53(3):1403-1418.
|
| 45 |
Kanamaru T, Kamimura N, Yokota T, et al. Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease[J]. Brain Res, 2015, 1605:49-58.
|
| 46 |
Kunst C, Schmid S, Michalski M, et al. The influence of gut microbiota on oxidative stress and the immune system[J]. Biomedicines, 2023, 11(5):1388.
|
| 47 |
Solesio ME, Prime TA, Logan A, et al. The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease[J]. Biochim Biophys Acta, 2013, 1832(1):174-182.
|
| 48 |
Jiang Y, Gao H, Yuan H, et al. Amelioration of postoperative cognitive dysfunction in mice by mesenchymal stem cell-conditioned medium treatments is associated with reduced inflammation, oxidative stress and increased BDNF expression in brain tissues[J]. Neurosci Lett, 2019, 709:134372.
|
| 49 |
Hoang DM, Pham PT, Bach TQ, et al. Stem cell-based therapy for human diseases[J]. Signal Transduct Target Ther, 2022, 7(1):272.
|
| 50 |
Deng S, Liu H, Qiu K, et al. Role of the golgi apparatus in the blood-brain barrier: golgi protection may be a targeted therapy for neurological diseases[J]. Mol Neurobiol, 2018, 55(6):4788-4801.
|
| 51 |
Zuo S, Ge H, Li Q, et al. Artesunate protected blood-brain barrier via sphingosine 1 phosphate receptor 1/phosphatidylinositol 3 kinase pathway after subarachnoid hemorrhage in rats[J]. Mol Neurobiol, 2017, 54(2):1213-1228.
|
| 52 |
Ong CW, Pabisiak PJ, Brilha S, et al. Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis[J]. J Neuroinflammation, 2017, 14(1):31.
|
| 53 |
Mechtouff L, Bochaton T, Paccalet A, et al. Matrix metalloproteinase-9 and monocyte chemoattractant protein-1 are associated with collateral status in acute ischemic stroke with large vessel occlusion[J]. Stroke, 2020, 51(7):2232-2235.
|
| 54 |
Barlow S, Brooke G, Chatterjee K, et al. Comparison of human placenta-and bone marrow-derived multipotent mesenchymal stem cells[J]. Stem Cells Dev, 2008, 17(6):1095-1107.
|
| 55 |
Al-Sammarraie SHA, Ayaz-Güner Ş, Acar MB, et al. Mesenchymal stem cells from adipose tissue prone to lose their stemness associated markers in obesity related stress conditions[J]. Sci Rep, 2024, 14(1):19702.
|
| 56 |
Asch A, Kalbermatten DF, Madduri S. Clinical safety and efficacy of allogeneic adipose stem cells: a systematic review of the clinical trials[J]. Int J Mol Sci, 2025, 26(13):6376.
|
| 57 |
李嘉鹏, 祖蕾娜·阿布拉, 贾谦谦, 等. 细胞来源外泌体应用于口腔组织再生的优势与潜力[J]. 中国组织工程研究, 2025:1-12.
|
| 58 |
Fischer UM, Harting MT, Jimenez F, et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect[J]. Stem Cells Dev, 2009, 18(5):683-692.
|
| 59 |
Su Y, Sun B, Gao X, et al. Intranasal delivery of targeted nanoparticles loaded with miR-132 to brain for the treatment of neurodegenerative diseases[J]. Front Pharmacol, 2020, 11:1165.
|
| 60 |
韩立, 惠利健, 潘国宇. 细胞的命运:间充质干细胞的药代动力学[J]. 中国细胞生物学学报, 2018, 40(6):857-866.
|
| 61 |
Huang S, Xu L, Sun Y, et al. The fate of systemically administrated allogeneic mesenchymal stem cells in mouse femoral fracture healing[J]. Stem Cell Res Ther, 2015, 6:206.
|
| 62 |
Stavrou M, Georgiou E, Kleopa KA. Lumbar intrathecal injection in adult and neonatal mice[J]. Curr Protoc, 2024, 4(6):e1091.
|
| 63 |
Shahir M, Mahmoud Hashemi S, Asadirad A, et al. Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells[J]. J Cell Physiol, 2020, 235(10):7043-7055.
|
| 64 |
Lang HL, Zhao YZ, Xiao RJ, et al. Small extracellular vesicles secreted by induced pluripotent stem cell-derived mesenchymal stem cells improve postoperative cognitive dysfunction in mice with diabetes[J]. Neural Regen Res, 2023, 18(3):609-617.
|
| 65 |
Zhang J, Huang X, Wang H, et al. The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy[J]. Stem Cell Res Ther, 2015, 6:234.
|
| 66 |
Yang C, Sun S, Zhang Q, et al. Exosomes of antler mesenchymal stem cells improve postoperative cognitive dysfunction in cardiopulmonary bypass rats through inhibiting the TLR2/TLR4 signaling pathway[J]. Stem Cells Int, 2020, 2020:2134565.
|
| 67 |
Wihadmadyatami H, Zulfikar MA, Herawati H, et al. Neuroprotection effect of bovine umbilical mesenchymal stem cell-conditioned medium on the rat model of Alzheimer's disease mediated by upregulation of BDNF and NGF and downregulation of TNF-α and IL-1β[J]. Open Vet J, 2025, 15(1):151-161.
|
| 68 |
Lee WJ, Cho KJ, and Kim GW. Mitigation of atherosclerotic vascular damage and cognitive improvement through mesenchymal stem cells in an Alzheimer's disease mouse model[J]. Int J Mol Sci, 2024, 25(23):13210.
|
| 69 |
Lin L, Huang L, Huang S, et al. MSC-Derived extracellular vesicles alleviate NLRP3/GSDMD-Mediated neuroinflammation in mouse model of sporadic Alzheimer's disease[J]. Mol Neurobiol, 2024, 61(8):5494-5509.
|
| 70 |
Mincheva G, Moreno-Manzano V, Felipo V, et al. Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy[J]. Stem Cell Res Ther, 2024, 15(1):472.
|
| 71 |
Ma Y, She X, Liu Y, et al. MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism[J]. Commun Biol, 2024, 7(1):562.
|
| 72 |
Lee WS, Kim HJ, Kim KI, et al. Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: A phase IIb, randomized, placebo-controlled clinical trial[J]. Stem Cells Transl Med, 2019, 8(6):504-511.
|
| 73 |
Zhu Y, Huang C, Zheng L, et al. Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase Ⅰ/Ⅱ randomized, double-blind, placebo-controlled study[J]. Stem Cell Res Ther, 2024, 15(1):122.
|
| 74 |
Renesme L, Cobey KD, Lalu MM, et al. Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell-based therapeutics[J]. Cytotherapy, 2025, 27(2):146-168.
|