Basic research and clinical application of hair follicle-derived mesenchymal stem cells

doi:10.3877/cma.j.issn.2095-1221.2023.03.010

Abstract

Abstract:

Stem cell-based regenerative medicine become the hotspot in current medical research. Accumulating studies showed that human hair follicles contain various stem cell components, including but not limited to keratinocyte stem cells, melanocyte stem cells, mesenchymal stem cells (MSCs) and neural crest cells. These hair follicle-derived stem cells interact in a coordinated temporal and spacial manner to maintain hair follicle homeostasis. Hair follicle-derived mesenchymal stem cells (HF-MSCs) participate in hair generation, hair growth and hair follicle cycle and can be used as an essential autologous stem cell source to participate in tissue repair, organ reconstruction and gene therapy. This review focuses on advances of HF-MSCs in the basic medical research and their application in the treatment of various clinical diseases.

Key words: Hair follicle, Mesenchymal stem cells, Basic research, Clinical application

Jiuli Yuan, Dan Liu, Linli Li, Jinyu Liu. Basic research and clinical application of hair follicle-derived mesenchymal stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(03): 189-192.

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