Progress in the treatment of inflammatory arthritis with mesenchymal stem cells

doi:10.3877/cma.j.issn.2095-1221.2023.02.004

Abstract

Abstract:

Inflammatory arthritis (IA) is a group of chronic inflammatory diseases that influence multiple joints, including ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, and so on. And early diagnosis and treatment are critical for the prognosis of patients. Currently, non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biological agents are the main clinical drugs. However, some patients still suffer from poor efficacy, recurrence, and side effects. In recent years, mesenchymal stem cells (MSCs) have been increasingly applied in treating IA due to their advantages, such as various sources, easy access, strong differentiation potential, and immunomodulatory and anti-inflammatory abilities. This article reviewed the mechanisms, sources, dosages, administration methods, and efficacy of MSCs in treating IA, aiming to provide new ideas for the treatment of IA.

Key words: Inflammatory arthritis, Mesenchymal stem cells, Cell therapy

Xing Feng, Hongtao Jin, Jun Ma, Yongzhou Song, Aijing Liu. Progress in the treatment of inflammatory arthritis with mesenchymal stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(02): 87-92.

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IA病种	第一作者	样本量	MSCs种类	输注方式	输注次数	随访时间	疗效	不良反应
AS	Li ^[20]	5	UC-MSCs	静脉注射	1 ~ 3次	1年	有效	一过性轻微发热
AS	曲海洪^[21]	30	UC-MSCs	局部注射	1次	6个月	有效	无
RA合并AS	王黎明^[22]	2	UC-MSCs	静脉+局部注射	1次	4 ~ 14个月	有效	无
RA	álvaro-Gracia ^[28]	53	AD-MSCs	静脉注射	3次	6个月	有效	感染、发热、腔隙性脑梗死等
RA	Ghoryani ^[29]	9	BM-MSCs	静脉注射	1次	12个月	有效	无
PSA	De Jesus ^[43]	1	AD-MSCs	静脉注射	2次	12个月	不明显	无
PSA	Coutts ^[44]	1	UC-MSCs	静脉+关节腔注射	2次	12个月	有效	流感样症状
SLE关节炎	朱宁^[50]	18	UC-MSCs	静脉注射	2次	3个月	有效	无
SLE关节炎	白茹^[51]	10	UC-MSCs	静脉注射	3 ~ 5次	3年	有效	输注过程中发热、呕吐
JIA	Swart ^[59]	6	BM-MSCs	静脉注射	1 ~ 2次	3个月	有效	无
JIA	Wang ^[60]	10	UC-MSCs	静脉注射	2次	2年	有效	无

IA病种	第一作者	样本量	MSCs种类	输注方式	输注次数	随访时间	疗效	不良反应
AS	Li ^[20]	5	UC-MSCs	静脉注射	1 ~ 3次	1年	有效	一过性轻微发热
AS	曲海洪^[21]	30	UC-MSCs	局部注射	1次	6个月	有效	无
RA合并AS	王黎明^[22]	2	UC-MSCs	静脉+局部注射	1次	4 ~ 14个月	有效	无
RA	álvaro-Gracia ^[28]	53	AD-MSCs	静脉注射	3次	6个月	有效	感染、发热、腔隙性脑梗死等
RA	Ghoryani ^[29]	9	BM-MSCs	静脉注射	1次	12个月	有效	无
PSA	De Jesus ^[43]	1	AD-MSCs	静脉注射	2次	12个月	不明显	无
PSA	Coutts ^[44]	1	UC-MSCs	静脉+关节腔注射	2次	12个月	有效	流感样症状
SLE关节炎	朱宁^[50]	18	UC-MSCs	静脉注射	2次	3个月	有效	无
SLE关节炎	白茹^[51]	10	UC-MSCs	静脉注射	3 ~ 5次	3年	有效	输注过程中发热、呕吐
JIA	Swart ^[59]	6	BM-MSCs	静脉注射	1 ~ 2次	3个月	有效	无
JIA	Wang ^[60]	10	UC-MSCs	静脉注射	2次	2年	有效	无

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