Differentiation of stem cells into parathyroid cells and the progress of applying parathyroid cells to treat hypoparathyroidism

doi:10.3877/cma.j.issn.2095-1221.2018.03.008

Abstract

Abstract:

Stem cells are a kind of cells with the ability of self-replication, self-renewal, as well as the potential of multi-directional differentiation, and can produce a variety of differentiated cell types. Stem cells technology has been widely used in cell transplantation because of their potential of self-renewal and multi-directional differentiation. Hypoparathyroidism, as an endocrine disorder, can not be cured by available therapy strategies completely. The transplantation of parathyroid cells derived from stem cell for the treatment of hypothyroidism has attracted more and more attention. Until now, some papers reported that human embryonic stem cells, thymic epithelial cells and tonsil mesenchymal stem cells had been differentiated into parathyroid cells and showed potential prospects in treatment of hypoparathyroidism. This paper explains the differentiation of stem cells to parathyroid cells and summarizes the progress of applying stem cells-derived parathyroid cells in treatment of hypoparathyroidism.

Key words: Stem cells, Parathyroid cells, Differentiation, Hypoparathyroidism, Treatment

Jiali Li, Ruili Zhao. Differentiation of stem cells into parathyroid cells and the progress of applying parathyroid cells to treat hypoparathyroidism[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(03): 168-171.

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References 31

1	Dulak J, Szade K, Szade A, et al. Adult stem cells: hopes and hypes of regenerative medicine[J]. Acta Biochim Pol, 2015, 62(3):329-337.
2	李金泰，蓝升，刘毅. 3D打印干细胞技术用于组织器官重建的现状与思考[J]. 器官移植, 2017, 8(4):267-270.
3	Shi Y, Inoue H, Wu JC, et al. Induced pluripotent stem cell technology: decade of progress[J]. Nat Rev Drug Discov, 2017, 16(2):115-130.
4	张维绮，刘光慧. 基于人多潜能干细胞的人类疾病研究与治疗[J]. 生物化学与生物物理进展, 2011, 38(11):982-987.
5	Clarke BL, Brown EM, Collins MT, et al. Epidemiology and diagnosis of hypoparathyroidism[J]. J Clin Endocrinol Metab, 2016, 101(6):2284-2299.
6	Winer KK, Zhang B, Shrader JA, et al. Synthetic human parathyroid hormone 1-34 replacement therapy: A randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism[J]. J Clin Endocrinol Metab, 2012, 97(2):391-399.
7	Hsu Y, Hung CJ. Intramuscular and subcutaneous forearm parathyroid autograft hyperplasia in renal dialysis patients: a retrospective cohort study[J]. Surgery, 2015, 158(5):1331-1338.
8	Decker GA, Stark JH, Botha JR, et al. Allotransplantation of parathyroid cells[J]. Lancet, 1995, 345(8942):124.
9	Johannesson B, Sui L, Freytes DO, et al. Toward beta cell replacement for diabetes[J]. EMBO J, 2015, 34(7):841-855.
10	Graham A, Okabe M, Quinlan RG. The role of the endoderm in the development and evolution of the pharyngeal arches[J]. J Anat, 2005, 207(5):479-487.
11	Moore-Scott BA, Manley NR. Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs[J]. Dev Biol, 2005, 278(2):323-335.
12	Kelly OG, Pinson KI, Skarnes WC. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice[J]. Development, 2004, 131(12):2803-2815.
13	Brennan J, Lu CC, Norris DP, et al. Nodal signalling in the epiblast patterns the early mouse embryo[J]. Nature, 2001, 411(6840):965-969.
14	Vincent SD, Dunn NR, Hayashi S, et al. Cell fate decisions within the mouse organizer are governed by graded Nodal signals[J]. Genes Dev, 2003, 17(13):1646-1662.
15	de Caestecker M. The transforming growth factor-beta superfamily of receptors[J]. Cytokine Growth Factor Rev, 2004, 15(1):1-11.
16	Lu CC, Brennan J, Robertson EJ. From fertilization to gastrulation: axis formation in the mouse embryo[J]. Curr Opin Genet Dev, 2001, 11(4):384-392.
17	Sulzbacher S, Schroeder IS, Truong TT, et al. Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions[J]. Stem Cell Rev, 2009, 5(2):159-173.
18	Bingham EL, Cheng SP, Woods Ignatoski KM, et al. Differentiation of Human Embryonic Stem Cells to a Parathyroid-Like Phenotype[J]. Stem Cells Dev, 2009, 18(7):1071-1080.
19	Woods Ignatoski KM, Bingham EL, Frome LK, et al. Differentiation of precursors into parathyroid-like cells for treatment of hypoparathyroidism[J]. Surgery, 2010, 148(6):1186-1190.
20	D'Amour KA, Agulnick AD, Eliazer S, et al. Efficient differentiation of human embryonic stem cells to definitive endoderm[J]. Nat Biotechnol, 2005, 23(12):1534-1541.
21	Woods Ignatoski KM, Bingham EL, Frome LK, et al. Directed Trans-Differentiation of Thymus Cells into Parathyroid-Like Cells Without Genetic[J]. Tissue Eng Part C Methods, 2011, 17(11):1051-1059.
22	Mouiseddine M, Mathieu N, Stefani J, et al. Characterization and histological localization of multipotent mesenchymal stromal cells in the human postnatal thymus[J]. Stem Cells Dev, 2008, 17(6):1165-1174.
23	Ryu KH, Cho KA, Park HS, et al. Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic factors for successful banking[J]. Cytotherapy, 2012, 14(10):1193-1202.
24	Park YS, Kim HS, Jin YM, et al. Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy[J]. Biomaterials, 2015, 65:140-152.
25	Lee Y, Bae JW, Oh DH, et al. In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties[J]. J Mater Chem B, 2013, 1: 2407-2414.
26	Park YS, Lee Y, Jin YM, et al. Sustained release of parathyroid hormone via in situ cross-linking gelatin hydrogels improves the therapeutic potential of tonsil-derived mesenchymal stem cells for hypoparathyroidism[J]. J Tissue Eng Regen Med, 2018, 12(3):e1747-e1756.
27	Choi YY, Chung BG, Lee DH, et al. Controlled-size embryoid body formation in concave microwell arrays[J]. Biomaterials, 2010, 31(15):4296-4303.
28	Park JY, Lee DH, Lee EJ, et al. Study of cellular behaviors on concave and convex microstructures fabricated from elastic PDMS membranes[J]. Lab Chip, 2009, 9(14):2043-2049.
29	Park YS, Hwang JY, Jun Y, et al. Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells[J]. Acta Biomater, 2016, 35:215-227.
30	Zhou Y, Lv BJ, Xu P, et al. Optimising gene therapy of hypoparathyroidism with hematopoietic stem cells[J]. Chin Med J, 2005, 118(3):204-209.
31	ZhaoY, Luo B. Adipose-derived stem cells: A novel source of parathyroid cells for treatment of hypoparathyroidism[J]. Med Hypotheses, 2016, 93:143-145.

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