A review of mesenchymal stem cells behavior regulated by physical cues

doi:10.3877/cma.j.issn.2095-1221.2017.02.008

Abstract

Abstract:

Mesenchymal stem cells (MSCs) have become an ideal cells source for the tissue engineering and regenerative medicine, because of their multipotency, easy access, no tumorogenesis risk and no ethical controversy. There are many problems in the process of stem cells therapy and tissue regeneration, such as the uncertain behavior of stem cell migration and differentiation in vivo. In recent years, more attention has been paid in designing biomaterials to regulate stem cells fate. The parameters of biomaterials can be designed to deliver biophysical and biochemical cues and regulate stem cells behavior and physiological function. This review will focus on the function and mechanism of stem cells regulated by various biophysical cues such as topography, mechanical and electric cues.

Key words: Mesenchymal stem cells, Signal transduction, Regulation, Review

Shenglian Yao, Xiumei Wang, Luning Wang. A review of mesenchymal stem cells behavior regulated by physical cues[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(02): 107-111.

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