A review of mesenchymal stem cells behavior regulated by physical cues

doi:10.3877/cma.j.issn.2095-1221.2017.02.008

Abstract

Abstract:

Mesenchymal stem cells (MSCs) have become an ideal cells source for the tissue engineering and regenerative medicine, because of their multipotency, easy access, no tumorogenesis risk and no ethical controversy. There are many problems in the process of stem cells therapy and tissue regeneration, such as the uncertain behavior of stem cell migration and differentiation in vivo. In recent years, more attention has been paid in designing biomaterials to regulate stem cells fate. The parameters of biomaterials can be designed to deliver biophysical and biochemical cues and regulate stem cells behavior and physiological function. This review will focus on the function and mechanism of stem cells regulated by various biophysical cues such as topography, mechanical and electric cues.

Key words: Mesenchymal stem cells, Signal transduction, Regulation, Review

Shenglian Yao, Xiumei Wang, Luning Wang. A review of mesenchymal stem cells behavior regulated by physical cues[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(02): 107-111.

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References 36

1	Sahni V, Kessler JA. Stem cell therapies for spinal cord injury[J]. Nat Rev Neurol, 2010, 6(7):363-372.
2	Park S, Suryaprakash S, Lao H, et al. Engineering mesenchymal stem cells for regenerative medicine and drug delivery[J]. Methods, 2015, 84(2015):3-16.
3	Abreu SC, Weiss DJ, Rocco PR. Extracellular vesicles derived from mesenchymal stromal cells: a therapeutic option in respiratory diseases?[J]. Stem Cell Res Ther, 2016, 7(1):53.
4	Murphy L, Mcdevitt C, Engler J. Materials as stem cell regulators[J]. Nat Mater, 2014, 13(6):547-557.
5	Lutolf P, Gilbert M, Blau M. Designing materials to direct stem-cell fate[J]. Nature, 2009, 462(7272):433-441.
6	Yao S, Liu X, Yu S, et al. Co-effects of matrix low elasticity and aligned topography on stem cell neurogenic differentiation and rapid neurite outgrowth[J]. Nanoscale, 2016, 8(19):10252-10265.
7	Aviss KJ, Gough JE, Downes S. Aligned electrospun polymer fibers for skeletal muscle regeneration[J]. Eur Cells Mater, 2010, 19(1):193-204.
8	Cho I, Choi S, Jeong Y, et al. Nerve growth factor (NGF)-conjugated electrospun nanostructures with topographical cues for neuronal differentiation of mesenchymal stem cells[J]. Acta Biomater, 2010, 6(12):4725-4733.
9	Berns J, Sur S, Pan L, et al. Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels[J]. Biomaterials, 2014, 35(1):185-195.
10	Peng R, Yao X, Cao B, et al. The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces[J]. Biomaterials, 2012, 33(26):6008-6019.
11	Peng R, Yao X, Ding J. Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion[J]. Biomaterials, 2011, 32(32):8048-8057.
12	Yao X, Peng R, Ding J. Effects of aspect ratios of stem cells on lineage commitments with and without induction media[J]. Biomaterials, 2013, 34(4):930-939.
13	Nair M, Elizabeth E. Applications of Titania nanotubes in bone biology[J]. J Nanosci Nanotechnol, 2015, 15(2):939-955.
14	Von Der Mark K, Park J, Bauer S, et al. Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix[J]. Cell Tissue Res, 2010, 339(1):131-153.
15	Oh S, Brammer KS, Li YS, et al. Stem cell fate dictated solely by altered nanotube dimension[J]. Proc Natl Acad Sci U S A, 2009, 106(7):2130-2135.
16	Pittrof A, Park J, Bauer S, et al. ECM spreading behaviour on micropatterned TiO2 nanotube surfaces[J]. Acta Biomater, 2012, 8(7):2639-2647.
17	Reilly C, Engler J. Intrinsic extracellular matrix properties regulate stem cell differentiation[J]. J Biomech, 2010, 43(1):55-62.
18	Engler AJ, Sen S, Sweeney HL, et al. Matrix elasticity directs stem cell lineage specification[J]. Cell, 2006, 126(4):677-689.
19	Park S, Chu S, Tsou D, et al. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β[J]. Biomaterials, 2011, 32(16):3921-3930.
20	Huebsch N, Arany PR, Mao AS, et al. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate[J]. Nat Mater, 2010, 9(6):518-526.
21	Parekh H, Chatterjee K, Sheng LG, et al. Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is Independent of myosin-based cytoskeletal tension[J]. Biomaterials, 2011, 32(9):2256-2264.
22	Steward J, Wagner R, Kelly J. The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure[J]. Eur Cell Mater, 2013, 25(1):167-178.
23	Huebsch N, Lippens E, Lee K, et al. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation[J]. Nat Mater, 2015, 14(12):1269-1277.
24	Engler J, Sweeney L, Discher E, et al. Extracellular matrix elasticity directs stem cell differentiation[J]. J Musculoskelet Neuronal Interact, 2007, 7(4):335.
25	Filipowska J, Reilly GC, Osyczka AM. A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage[J]. Biotechnol Bioeng, 2016, 113(8):1814-1824.
26	Huang Y, Hagar L, Frost E, et al. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells[J]. Stem Cells, 2004, 22(3):313-323.
27	Haudenschild K, Hsieh H, Kapila Sunil, et al. Pressure and distortion regulate human mesenchymal stem cell gene expression[J]. Ann Biomed Eng, 2009, 37(3):492-502.
28	Ward J, Salasznyk RM, Klees RF, et al. Mechanical strain enhances extracellular matrix-induced gene focusing and promotes osteogenic differentiation of human mesenchymal stem cells through an extracellular-related kinase-dependent pathway[J]. Stem Cells Dev, 2007, 16(3):467-479.
29	Rui F, Lui P, Ni M, et al. Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells[J]. J Orthop Res, 2011, 29(3):390-396.
30	Steward J, Kelly J. Mechanical regulation of mesenchymal stem cell differentiation[J]. J Anat, 2015, 227(6):717-731.
31	Dahl KN, Ribeiro AJ, Lammerding J. Nuclear shape, mechanics, and mechanotransduction[J]. Circ Res, 2008, 102(11):1307-1318.
32	Haase K, Macadangdang JK, Edrington CH, et al. Extracellular forces cause the nucleus to deform in a highly controlled anisotropic manner[J]. Sci Rep, 2016, 6:21300.
33	Creecy M, O'neill F, Arulanandam P, et al. Mesenchymal stem cell osteodifferentiation in response to alternating electric current[J]. Tissue Eng Part A, 2013, 19(3/4):467-474.
34	Guo W, Zhang X, Yu X, et al. Self-Powered electrical stimulation for enhancing neural differentiation of mesenchymal stem cells on Graphene-Poly(3,4-ethylenedioxythiophene) hybrid microfibers[J]. ACS Nano, 2016, 10(5):5086-5095.
35	Du L, Fan H, Miao H, et al. Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells[J]. Bioelectromagnetics, 2014, 35(7):519-530.
36	Kim EC, Leesungbok R, Lee SW, et al. Effects of moderate intensity static magnetic fields on human bone marrow-derived mesenchymal stem cells[J]. Bioelectromagnetics, 2015, 36(4):267-276.

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