Abstract:
Objective
To investigate the clinical efficacy of polymyxin B combined with other antibiotics in the treatment of severe infection after hematopoietic stem cell transplantation.
Methods
Clinical data of 58 patients with severe infection after hematopoietic stem cell transplantation treated with polymyxin B combined with other antibiotics were retrospectively analyzed. Patients were divided into 2 groups based on the duration of polymyxin B treatment[≤7 d group （27 cases） ， ＞ 7 d group （31 cases）］. The total bacterial clearance rate and effective rate were compared between two groups. The quantitative data between the two groups were compared by independent sample t test or Mann-Whitney U test， and the qualitative data between the two groups were compared by χ2 test or Fisher exact test. Survival data between the two groups were compared using Kaplan-Meier survival curve method.
Results
Compared with the treatment duration ≤7 days group， the total bacterial clearance rate （48.39% vs 22.22%） and treatment effectiveness（70.97%vs 44.44%） were increased in the treatment duration ＞ 7 days group.
Conclusion
For patients with severe infection after hematopoietic stem cell transplantation， polymyxin B should be combined with other anti-infective drugs for a full course of treatment to benefit patients.
Key words:
Hematopoietic stem cell transplantation,
Polymyxin B,
Carbapenemresistant,
Gram-negative bacteria
Xintong Li, Yanhua Zheng, Ruilin Ren, Min Xu, Chunxiao He, Xuemei Wen, Nainong Li, Xiaofan Li. Clinical efficacy of polymyxin B in the treatment of severe infection after hematopoietic stem cell transplantation[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2025, 15(01): 51-56.