Advances in the application of mesenchymal stem cells-derived nanovesicle in various diseases

doi:10.3877/cma.j.issn.2095-1221.2025.01.007

Abstract

Abstract:

Mesenchymal stem cell derived nanovesicles （MSCNVs） represent an innovative cellular therapy alternative， characterized by high stability and reduced size， with therapeutic potential validated across various fields， including the nervous system disease， cardiovascular health，inflammatory diseases， as well as tissue regeneration and repair. Studies indicate that nanovesicles（NVs） exert positive effects on disease treatment and tissue repair through mechanisms such as promoting tissue regeneration， alleviating inflammatory responses， and modulating immune responses. However， MSCNVs still confront challenges regarding efficacy and long-term safety in current disease applications， necessitating further research and optimization. This review integrates the latest research findings and experimental data， providing a systematic analysis of the applications and therapeutic efficacy of MSCNVs in the treatment of various diseases， offering a comprehensive and updated perspective on the potential value of MSCNVs in disease therapy.

Key words: Mesenchymal stem cells, Nanovesicles, Therapy, Assessment

Xinyi Zhuo, Yuchong Zhu, Junquan Liu, Yuqin Liao. Advances in the application of mesenchymal stem cells-derived nanovesicle in various diseases[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2025, 15(01): 57-62.

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References 65

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作者	疾病领域	MSCs	来源主要结果
Kim等^［8］	神经系统（左大脑中动脉闭塞造模）	人骨髓	梗死面积减少；运动能力提高
Bucan 等^［37］	神经系统	大鼠脂肪	神经突生长增加，坐骨功能指数改善
Lee 等^［9］	心血管	人骨髓	炎症减少；心功能修复能力提高
Jiang 等^［38］	心血管	小鼠骨髓	动脉粥样硬化斑块靶向增强；胆固醇累积减少
Park 等^［10］	炎症性疾病	人骨髓	眼部渗出现象减少；介导炎症细胞数量降低
Ma 等^［39］	组织再生修复	人脐带	伤口愈合率增加；炎症减轻
Han 等^［11］	组织再生修复	小鼠骨髓	加速成纤维细胞的增殖和迁移；加速血管形成
Neupane 等^［40］	组织再生修复	人脐带	促进血管生成；加速伤口愈合
Kim 等^［41］	组织再生修复	人骨髓	诱导内皮细胞血管生成；发挥神经保护作用

作者	疾病领域	MSCs	来源主要结果
Kim等^［8］	神经系统（左大脑中动脉闭塞造模）	人骨髓	梗死面积减少；运动能力提高
Bucan 等^［37］	神经系统	大鼠脂肪	神经突生长增加，坐骨功能指数改善
Lee 等^［9］	心血管	人骨髓	炎症减少；心功能修复能力提高
Jiang 等^［38］	心血管	小鼠骨髓	动脉粥样硬化斑块靶向增强；胆固醇累积减少
Park 等^［10］	炎症性疾病	人骨髓	眼部渗出现象减少；介导炎症细胞数量降低
Ma 等^［39］	组织再生修复	人脐带	伤口愈合率增加；炎症减轻
Han 等^［11］	组织再生修复	小鼠骨髓	加速成纤维细胞的增殖和迁移；加速血管形成
Neupane 等^［40］	组织再生修复	人脐带	促进血管生成；加速伤口愈合
Kim 等^［41］	组织再生修复	人骨髓	诱导内皮细胞血管生成；发挥神经保护作用

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