Regulatory significance and research progress of extracellular vesicle-mediated glial interactions on neuroinflammation

doi:10.3877/cma.j.issn.2095-1221.2023.04.006

Abstract

Abstract:

Neuroinflammation serves as both a causative factor and secondary response in central nervous system (CNS) diseases such as epilepsy, Alzheimer's disease, and brain injury, as well as is an important mechanism of the disease initiation and progression. Notably, glial cells play an important role in regulating neuroinflammation, and the interactions between microglia and astrocytes have a key regulatory significance in CNS inflammation. Additionally, extracellular vesicles (EVs) have inflammatory modulation and neuroprotective functions in CNS injuries. Therefore, this review summarized the regulatory functions of astrocytes, microglia, and their interactions in the CNS, elucidated the regulatory significance of endogenous EVs in neuroinflammatory diseases, and explored the regulatory mechanisms of exogenous EVs on the interaction between astrocytes and microglia, aiming further to investigate the pathogenesis and treatment of CNS diseases .

Key words: Extracellular vesicles, Microglia, Astrocyte, Cell interactions, Neuroinflammation

Xiaoyan Liu, Qianfa Long, Junxiu Xi, Minghao Du, Xiaohuan Huang. Regulatory significance and research progress of extracellular vesicle-mediated glial interactions on neuroinflammation[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(04): 235-241.

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