Research progress on the effects of mesenchymal stem cell-derived exosomes on the biological behaviour of preeclamptic trophoblast cells

doi:10.3877/cma.j.issn.2095-1221.2022.05.008

Abstract

Abstract:

Preeclampsia (PE) is a unique complication in the second and third trimesters of pregnancy that seriously affects the perinatal outcome of pregnant women. Its specific pathogenesis is still unclear, and there is currently no effective treatment. As the main mode of the paracrine effect of mesenchymal stem cells (MSCs) , exosomes play an essential role in the communication of information between cells. Exosomes that carry small molecules such as micorRNAs have also been found to be involved in a physiological and pathological process. In recent years, related studies have found that exosomes from different sources of MSCs can provide a potential therapeutic method for treating PE by improving the function of trophoblast cells. It is believed that with the continuous deepening of research, MSCs from different sources and their exosomes will play amassive potential in the targeted drug therapy of patients with PE, reducing the incidence of adverse perinatal outcomes and ensuring the safety of mothers and babies. This article will describe the essential characteristics of MSCs from different sources and analyze the therapeutic effect of exosomes in PE trophoblast cells to provide new perspectives and ideas for the clinical treatment of PE.

Key words: Mesenchymal stem cells, Preeclampsia, Paracrine, Exosomes, miRNA

Doudou He, Xiaotong Sun, Tao Qu, Zhongyuan Li, Xueping Yang. Research progress on the effects of mesenchymal stem cell-derived exosomes on the biological behaviour of preeclamptic trophoblast cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(05): 309-313.

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