Research progress of adipose-derived stem cells in the treatment of chronic wounds

doi:10.3877/cma.j.issn.2095-1221.2022.04.007

Abstract

Abstract:

Various methods are used to treat wounds clinically, but there are still many difficulties in the treatment of chronic wounds due to excessive inflammatory response, difficulties in epithelialization, vascularization, and other factors. With the increasing research on adipose-derived stem cells (ADSCs) in recent years, many evidences show that ADSCs scan promote the healing of chronic wounds by regulating macrophages function and cellular immunity, promoting angiogenesis and epithelialization. In order to provide reference for the stem cell therapy of chronic wounds, this paper reviewed the difficulties in the treatment of chronic wounds, the advantages and the mechanism of ADSCs in promoting the healing of chronic wounds.

Key words: Adipose-derived stem cells, Chronic wounds, Healing, Immunoregulation

Zhuolun Hao, Wenli Qi, Jiaming Sun, Muran Zhou, Nengqiang Guo. Research progress of adipose-derived stem cells in the treatment of chronic wounds[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(04): 237-242.

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References 43

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ADSCs促进创面愈合的不同机制	调控方式	参考文献
对巨噬细胞的调控	分泌TGF-β，IL-1β和IL-6，并增加巨噬细胞募集	[25]
	分泌TNF、IL-10	[26,27]
	诱导合成Arg-1	[28]
对细胞免疫的调控	分泌PGE-2抑制DC过度成熟，减弱T细胞增殖	[30]
	抑制T细胞分化活化，降低IFN-γ	[31]
	介导抗CD3、CD2、CD28刺激物，抑制T细胞活化	[32]
促血管生成	分泌hVEGF、TGF-β、IL-6	[36]
	与血管内皮细胞和巨噬细胞相互作用，增加MCP-1和hVEGF分泌	[37]
促上皮化调控细胞外基质	刺激TGF-β受体和纤维蛋白表达增加	[39]
	含有ADSCs的AT-Ex增强真皮和表皮细胞增殖	[40]
	上调Ⅲ型胶原蛋白与Ⅰ型胶原蛋白的比例	[42]

ADSCs促进创面愈合的不同机制	调控方式	参考文献
对巨噬细胞的调控	分泌TGF-β，IL-1β和IL-6，并增加巨噬细胞募集	[25]
	分泌TNF、IL-10	[26,27]
	诱导合成Arg-1	[28]
对细胞免疫的调控	分泌PGE-2抑制DC过度成熟，减弱T细胞增殖	[30]
	抑制T细胞分化活化，降低IFN-γ	[31]
	介导抗CD3、CD2、CD28刺激物，抑制T细胞活化	[32]
促血管生成	分泌hVEGF、TGF-β、IL-6	[36]
	与血管内皮细胞和巨噬细胞相互作用，增加MCP-1和hVEGF分泌	[37]
促上皮化调控细胞外基质	刺激TGF-β受体和纤维蛋白表达增加	[39]
	含有ADSCs的AT-Ex增强真皮和表皮细胞增殖	[40]
	上调Ⅲ型胶原蛋白与Ⅰ型胶原蛋白的比例	[42]

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