Adipose derived stem cells for myocardial injury repair: a review

doi:10.3877/cma.j.issn.2095-1221.2022.04.006

Abstract

Abstract:

Stem cell therapy has been widely used in the research of heart-related diseases. Adipose-derived stem cells (ADSCs) , as a kind of adult stem cells, are easily obtained and expanded, and have multi-directional differentiation potential. It has been demonstrated that ADSCs have the ability to differentiate into myocyte-like cells, vascular smooth muscle cells and endothelial cells, and became an important source of adult stem cells for the treatment of cardiovascular diseases. Furthermore, ADSCs secrete a series of paracrine factors that can promote neovascularization, reduce apoptosis, and inhibit fibrosis, and have great potential in promoting the repair of myocardial injury. But ADSCs still face the problem of low survival rate. Here, we focus on reviewing the leading edge of the ADSCs therapeutic mechanisms and strategies for improving therapeutic effectiveness.

Key words: Adipose-derived stem cells, Acute myocardial infarction, Myocardial injury repair, Repair mechanism, Clinical application

Liang Qiao, Xiangqun Yang. Adipose derived stem cells for myocardial injury repair: a review[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(04): 230-236.

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