Modular and vascularized tissue engineering techniques

doi:10.3877/cma.j.issn.2095-1221.2022.03.005

Abstract

Abstract:

Large-scale complex organ construction is a major challenge for tissue engineering construction technology in the future. There are two core issues, one is how to establish anastomotic vascular circulation in operable centimeter-sized organs, and the another is how to simulate the cell distribution in native tissues. Modular tissue engineering technology is a construction concept based on the "bottom-up" theory. In theory, this technology can fundamentally solve the above problems. With the in-depth research of stem cells and biomaterials, organoids and bioprinting technologies emerge in an endless stream, and construction technologies also need to be developed accordingly. Eventually, the model of overall implantation of artificial tissues will be changed to "living organ" transplantation with vascular pedicle anastomosis.

Key words: Modularization, Tissue engineering, Biological manufacturing, Organ repair, In vitro construction, Vascularization

Yingqian Zhou, Zhenxing Wang, Yifan Zhang, Jiaming Sun, Yilin Cao. Modular and vascularized tissue engineering techniques[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(03): 161-166.

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