Progress on cardiovascular progenitor cell induction, proliferation, differentiation and applications

doi:10.3877/cma.j.issn.2095-1221.2019.02.009

Abstract

Abstract:

Cardiovascular progenitor cells (CPCs) are multipotent stem cells with differentiation potential into cardiomyocytes (CMs), endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) during embryonic development or in adult tissues. The application of pluripotent stem cells (PSCs) directed differentiation technology can also directly obtain CPCs in vitro. CPCs could not only provide a cell model for studying the molecular mechanism of differentiation of cardiovascular cells, but also a promising cell resource for cardiovascular regeneration. However, the mechanisms of induction, self-renewal and differentiation of CPCs are still incompletely understood, which limited their applications in cardiovascular cell therapy. This review will focus on the various markers of CPCs and the signaling regulation on CPCs induction, proliferation, differentiation, as well as the applications in cardiovascular regeneration.

Key words: Cardiovascular progenitor cells, Pluripotent stem cells, Differentiation, Cell therapy, Cardiovascular regeneration

Xu Jiang, Yongyu Wang. Progress on cardiovascular progenitor cell induction, proliferation, differentiation and applications[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(02): 119-123.

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