Acute cardiac infarction is caused by acute cardiac ischemia due to stensis of coronary artery and its branches. Serious cardiac ischemia may cause necrosis of heart cells and scar around the infarction area may cause heart dysfunction and remolding, leading to heart faiure. Stem cells derived from cardiac tissue itself, referred to as cardiosphere-derived cells (CDCs), may give rise to muscular cells and vascular endothelial cells in vitro and trigger native cardiomyocyte proliferation and recruitment of endogenous progenitor cells via paracrine effects. Mediators involved in paracrine signaling can be used as a stem cell-free therapy, with all the benefits and none of the associated complications of stem cells. Large-scale clinical trials are needed to confirm the long-term efficacy of CDC.