Mesenchymal stem cells in the treatment of acute radiation-induced injury

doi:10.3877/cma.j.issn.2095-1221.2018.02.009

Abstract

Abstract:

Acute radiation injury is one of serious complication of exposure to irradiation, but there is still no effective means to prevent and treat it. However, mesenchymal stem cells (MSCs) are self-renewal and differentiating into various cell lineages. These cells possess attributes such as secreting a variety of cytokines, anti-inflammatory and immunosuppressive properties. The advantages of MSCs in tissue-repaired is conspicuous, but the timing and doses of transplants have been controversial. The safety problems such as tumorigenicity restrict clinical trials. Recently, the result of cell-free transplantation is fruitful, and the new situation definitely comes soon. This review summarizes and discusses recent advances on MSCs treating severe acute radiation.

Key words: Mesenchymal stem cells MSCs, Radiation injury, Cell therapy

Fei Xue, Pingping Huang. Mesenchymal stem cells in the treatment of acute radiation-induced injury[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(02): 120-124.

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时间	研究者	例数	损伤类型	移植细胞类型	治疗时间	治疗剂量	效果
2007	艾辉胜等^[40]	2	肠型放射病、极重度骨髓放射病	异基因造血干细胞联合BM-MSCs	照射后		恢复造血，未发生GVHD
					5 ~ 6 d	3.60×10⁶/kg
					CD34移植后14 d	5.80×10⁶/kg
2009	Kursova LV等^[41]	11	放射性肺损伤	BM-MSCs	—	6.25×10⁶/kg	症状好转
2009	Kursova LV等^[41]	11	放射性肺损伤	BM-MSCs	—	（1 ~ 2）×10⁸ cells	症状好转
2013	M Guo等^[42]	1	重度骨髓放射病、肠型放射病	BM-MSCs联合异基因外周血造血干细胞	受照后		造血恢复、肠道功能未恢复
					3 d	1.10×10⁷ cells/2ml
					8 d	1.55×10⁶ cells/2ml
					14 d	11.00×10⁷ cells/2ml
					23 d	6.30×10⁷ cells/2ml
					32 d	5.60×10⁷ cells/2ml
					37 d	5.10×10⁷ cells/2ml
					40 d	5.00×10⁷ cells/2ml
2016	刘玉龙等^[43]	1	轻度骨髓损伤、四度急性皮肤损伤	UC-MSCs	受照后		VEGF升高血象恢复；皮肤损伤愈合
					271 d	10.10×10⁷/U
					278 d	10.10×10⁷/U
2017	谯智慧等^[44]	8	放射性肺纤维化	UC-MSCs	受照后		呼吸道症状减轻、CT值好转
2017	谯智慧等^[44]	8	放射性肺纤维化	UC-MSCs	3.5个月	1.00×10⁶/kg	呼吸道症状减轻、CT值好转

时间	研究者	例数	损伤类型	移植细胞类型	治疗时间	治疗剂量	效果
2007	艾辉胜等^[40]	2	肠型放射病、极重度骨髓放射病	异基因造血干细胞联合BM-MSCs	照射后		恢复造血，未发生GVHD
					5 ~ 6 d	3.60×10⁶/kg
					CD34移植后14 d	5.80×10⁶/kg
2009	Kursova LV等^[41]	11	放射性肺损伤	BM-MSCs	—	6.25×10⁶/kg	症状好转
2009	Kursova LV等^[41]	11	放射性肺损伤	BM-MSCs	—	（1 ~ 2）×10⁸ cells	症状好转
2013	M Guo等^[42]	1	重度骨髓放射病、肠型放射病	BM-MSCs联合异基因外周血造血干细胞	受照后		造血恢复、肠道功能未恢复
					3 d	1.10×10⁷ cells/2ml
					8 d	1.55×10⁶ cells/2ml
					14 d	11.00×10⁷ cells/2ml
					23 d	6.30×10⁷ cells/2ml
					32 d	5.60×10⁷ cells/2ml
					37 d	5.10×10⁷ cells/2ml
					40 d	5.00×10⁷ cells/2ml
2016	刘玉龙等^[43]	1	轻度骨髓损伤、四度急性皮肤损伤	UC-MSCs	受照后		VEGF升高血象恢复；皮肤损伤愈合
					271 d	10.10×10⁷/U
					278 d	10.10×10⁷/U
2017	谯智慧等^[44]	8	放射性肺纤维化	UC-MSCs	受照后		呼吸道症状减轻、CT值好转
2017	谯智慧等^[44]	8	放射性肺纤维化	UC-MSCs	3.5个月	1.00×10⁶/kg	呼吸道症状减轻、CT值好转

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