Current studies on cytokines and signal pathways involved in bone marrow mesenchymal stem cells differentiation into hepatocytes cells

doi:10.3877/cma.j.issn.2095-1221.2018.01.011

Abstract

Abstract:

Bone marrow stem cells include hematopoietic stem cells and mesenchymal stem cells. Bone marrow mesenchymal stem cells (BMSCs) are a kind of cells with properties of self-renewal, proliferation and multi-directional differentiation, and have the characteristic of asymmetric cell division and unlimited proliferation. Under the influences of hepatocyte growth factor (HGF), BMSCs can differentiate into liver cells, and related signaling pathways involved in the differentiation process include NF-kB signal pathways, Notch signal pathways, MAPK signal pathways, Wnt signal pathways and STAT3 signal pathways. The related signaling pathways of BMSCs differentiation into hepatocytes are reviewed in this article.

Key words: Bone marrow mesenchymal stem cells, Hepatocyte(-like) cells, Signal pathways, Differentiation

Jiacheng Chen, Nian Fu, Youjiao Huang, Hongjun Quan. Current studies on cytokines and signal pathways involved in bone marrow mesenchymal stem cells differentiation into hepatocytes cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(01): 59-62.

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