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Chinese Journal of Cell and Stem Cell(Electronic Edition) ›› 2018, Vol. 08 ›› Issue (01): 49-52. doi: 10.3877/cma.j.issn.2095-1221.2018.01.009

Special Issue:

• Review • Previous Articles     Next Articles

Molecular mechanism and application of kidney organoids from pluripotent cells

Denglu Zhang1, Xiaohang Du2, Feng Kong2, Shengtian Zhao3,()   

  1. 1. Central Laboratory, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China; Key Laboratory of Kidney Regeneration of Shandong Province, Jinan 250033, China
    2. Key Laboratory of Kidney Regeneration of Shandong Province, Jinan 250033, China
    3. Department of Urology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China; Key Laboratory of Kidney Regeneration of Shandong Province, Jinan 250033, China
  • Received:2016-09-30 Online:2018-02-01 Published:2018-02-01
  • Contact: Shengtian Zhao
  • About author:
    Corresponding author: Zhao Shengtian, Email:

Abstract:

Stem cells with the potential of self-renewal and multilineage differentiation play an increasingly important role in the field of regenerative medicine. Kidney organoids, a kind of tissue structure with certain renal function that derived from stem cells, could be used for cell repair therapy of renal diseases, or for imitating kidney development and disease occurrence so as to screen the drugs which could improve renal function. The culture of kidney organoids in vitro becomes a research hotspot at present. The in vitro culture could be divided into several stages as follows: stem cells-primordial somatic mesoderm-intermediate mesoderm-ureteric bud/metanephric mesenchyme-collecting tube/nephron. Two kinds of more mature in vitro induction methods of kidney organoids at present are focused on and the application prospect of kidney organoids are reviewed.

Key words: Pluripotent stem cells, Kidney, Organoid, Induced differentiation

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