Progress in role of mesenchymal stem cells in tumor biology

doi:10.3877/cma.j.issn.2095-1221.2018.01.008

Abstract

Abstract:

During the last half a century, studies have shown that mesenchymal stem cells (MSCs), one of the important cellular components in tumor microenvironment, play important roles in multiple hallmarks of cancer including cell growth, proliferation, apoptosis, invasion and metastasis, angiogenesis, energy metabolism and treatment resistance. Meanwhile, the underlying molecular mechanisms have gradually been revealed. Accordingly, based on these new findings, research regarding the possible clinical application of MSCs with genetic modification and/or physical/chemical pre-treatment in systematic treatment of cancer have yielded impressing results. In this review, we summarized the current advances in biological roles of MSCs in the tumorigenesis and progression of the malignant tumor and the correlated molecular mechanisms. The new research horizons and the possible clinical application of MSCs in cancer therapy are also prospected.

Key words: Mesenchymal stem cells, Tumor microenvironment, Tumor biology

Tingting Lin, Qun Ren. Progress in role of mesenchymal stem cells in tumor biology[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(01): 39-48.

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