Effects of butylphthalide combined with ganglioside on lactic acid clearance rate and T cells in patients with acute severe carbon monoxide poisoning

doi:10.3877/cma.j.issn.2095-1221.2017.02.003

Abstract

Abstract:

Objective

To investigate the effect of butylphthalide combined with ganglioside on lactic acid clearance rate and T cells in patients with severe acute carbon monoxide poisoning.

Methods

Ninty four patients with acute severe carbon monoxide poisoning were enrolled from our hospital from June 2014 to June 2016 and randomized into the experimental group (n= 47) and the control group (n= 47) using a random number table. The control group was given ganglioside and the experimental group ganglioside and butylphthalide for 4 weeks. Blood lactate clearance rate, delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) incidence, GCS score and immune function indexes were compared between the two groups. Data analysis was performed using SPSS16.0 statistical software.

Results

The efficiency of theexperimental group (93.62﹪) was higher than that of the control group (74.47﹪) (χ²= 6.425, P< 0.05) ; GCS scores of both groups increased (P< 0.05) ; patients in the experimental group hadhigher GCS score after treatment (14.23±1.69) than the control group (11.35±1.45,t= 8.867,P< 0.05) ; the experimental group also had higher 24 h blood lactate clearance rate (65.98±4.52) ﹪than the control group (41.39﹪±3.67﹪,P< 0.05) ; In both groups the percentages of CD3⁺and CD4⁺cells and CD4⁺ (CD8⁺) ratio increased, but the percentage of CD8⁺cells decreased (P< 0.05) after treatment; the experimental group had higher percentages of CD3⁺cells (62.30±4.19) ﹪and CD4⁺cells (62.30±4.19) ﹪, and higher CD4⁺ (CD8⁺) ration (1.64±0.31) than the control group[CD3⁺cell: (57.12±3.76) ﹪, CD4⁺cells: (38.91±3.10) ﹪, CD4⁺ (CD8⁺) ratio: (1.34±0.24) , but lower CD8⁺cell percentage (25.78﹪±2.18﹪vs 29.08﹪±2.31﹪,t= 6.308, 4.755, 5.246, and 7.123 respectively,P< 0.05]; the experimental group had lower incidence of DEACMP (4.26﹪) than the control group (23.40﹪) (χ²= 7.231,P< 0.05) .

Conclusion

Butylphthalide combined with ganglioside is more effective than ganglioside alone for the treatment of acute severe carbon monoxide poisoning, with improved lactate clearance rate and immune function.

Key words: Propiophenones, Gangliosides, Carbon monoxide poisoning, Lactic acid, Metabolic clearance rate, T-Lymphocytes

Junji Li, Xiaoping Li. Effects of butylphthalide combined with ganglioside on lactic acid clearance rate and T cells in patients with acute severe carbon monoxide poisoning[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(02): 77-80.

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References 15

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分组	例数	治愈[n（﹪）]	显效[n（﹪）]	有效[n（﹪）]	无效[n（﹪）]	总有效率（﹪）
观察组	47	13（27.66）	21（44.68）	10（21.28）	3（6.38）	93.62^*
对照组	47	6（12.77）	16（34.04）	13（27.66）	12（25.53）	74.47

分组	例数	治愈[n（﹪）]	显效[n（﹪）]	有效[n（﹪）]	无效[n（﹪）]	总有效率（﹪）
观察组	47	13（27.66）	21（44.68）	10（21.28）	3（6.38）	93.62^*
对照组	47	6（12.77）	16（34.04）	13（27.66）	12（25.53）	74.47

分组	例数	治疗前	治疗后	t值	P值
观察组	47	4.09±0.87	14.23±1.69	36.572	<0.001
对照组	47	4.15±0.91	11.35±1.45	28.834	< 0.001
t值	?	0.327	8.867	?	?
P值	?	0.612	< 0.001	?	?

分组	例数	治疗前	治疗后	t值	P值
观察组	47	4.09±0.87	14.23±1.69	36.572	<0.001
对照组	47	4.15±0.91	11.35±1.45	28.834	< 0.001
t值	?	0.327	8.867	?	?
P值	?	0.612	< 0.001	?	?

分组	例数	CD3⁺		CD4⁺		CD8⁺		CD4⁺（CD8⁺）
分组	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	47	53.42±3.46	62.30±4.19^*	34.29±3.14	42.36±3.89^*	33.17±2.87	25.78±2.18^*	1.03±0.25	1.64±0.31^*
对照组	47	52.76±4.08	57.12±3.76^*	33.47±3.25	38.91±3.10^*	33.36±2.67	29.08±2.31^*	1.00±0.28	1.34±0.24^*
t值	?	0.408	6.308	1.244	4.755	0.332	5.246	0.548	7.123
P值	?	0.576	< 0.001	0.102	< 0.001	0.598	< 0.001	?	?

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