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中华细胞与干细胞杂志(电子版) ›› 2025, Vol. 15 ›› Issue (03) : 179 -189. doi: 10.3877/cma.j.issn.2095-1221.2025.03.006

论著

基于CiteSpace 对结直肠癌铁死亡研究现状的可视化分析
陈明付1, 王庆惠1, 纪辉涛1, 陈银珍1, 余小娟2, 陈怀章3, 赵虎1,3,4, 王瑜1,2,3,4,()   
  1. 1. 350025 福州,福建中医药大学福总教学医院 (第九〇〇医院)普通外科
    2. 350025 福州,厦门大学附属东方医院普通外科
    3. 350025 福州,福建医科大学福总临床医学院普通外科
    4. 350025 福州,中国人民解放军联勤保障部队第九〇〇医院普通外科
  • 收稿日期:2025-02-28 出版日期:2025-06-01
  • 通信作者: 王瑜
  • 基金资助:
    福建省自然科学基金面上项目 (2024J011155)

The visualization analysis of the current research status on ferroptosis in colorectal cancer using CiteSpace

Mingfu Chen1, Qinghui Wang1, Huitao Ji1, Yinzhen Chen1, Xiaojuan Yu2, Huaizhang Chen3, Hu Zhao1,3,4, Yu Wang1,2,3,4,()   

  1. 1. Department of General Surgery, Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou 350025, China
    2. Department of General Surgery, Dongfang Hospital of Xiaen University, School of Medicine, Xiamen University,Fuzhou 350025, China
    3. Department of General Surgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China
    4. Department of General Surgery,900th Hospital of PLA Joint Logistic Support Force, Fuzhou 350025, China
  • Received:2025-02-28 Published:2025-06-01
  • Corresponding author: Yu Wang
引用本文:

陈明付, 王庆惠, 纪辉涛, 陈银珍, 余小娟, 陈怀章, 赵虎, 王瑜. 基于CiteSpace 对结直肠癌铁死亡研究现状的可视化分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2025, 15(03): 179-189.

Mingfu Chen, Qinghui Wang, Huitao Ji, Yinzhen Chen, Xiaojuan Yu, Huaizhang Chen, Hu Zhao, Yu Wang. The visualization analysis of the current research status on ferroptosis in colorectal cancer using CiteSpace[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2025, 15(03): 179-189.

目的

基于文献计量学方法对结直肠癌铁死亡相关研究进行可视化分析,探讨2017 年至2024 年该领域的研究热点及发展趋势。

方法

检索Web of Science 核心合集数据库、中国知网 (CNKI)、万方数据库和维普数据库2017 年1 月1 日至2024 年12 月31 日发表的相关文献,利用CiteSpace 6.4.R1 和Microsoft Excel 2016 进行发文量、国家、机构、期刊和关键词的可视化分析,以及关键词共现和聚类分析。

结果

共纳入739 篇文献,其中英文文献598 篇,中文文献141 篇。分析结果表明,2017 年至2019 年论文发表量相对较低,但自2020 年起,相关研究的发文量增加。在全球范围内,中国是发文量最多的国家;复旦大学为发文量最高的机构;《Frontiers in Oncology》为发表此类研究最多的期刊。通过关键词共现和聚类分析,揭示4 个核心研究主题,包括铁死亡的分子机制与代谢调控、铁死亡相关基因的表达与信号通路的调控、铁死亡与肿瘤免疫调控机制及基于铁死亡的临床治疗策略与干预措施。关键词突现分析表明,铁死亡调控机制和代谢调节是该领域持续的研究热点。近年来,研究焦点逐渐转向临床应用,特别关注内质网应激、干细胞技术、光动力治疗和炎症反应的研究。

结论

结直肠癌铁死亡研究正处于快速发展阶段。对结直肠癌中铁死亡机制的探讨及其临床应用,是目前的研究热点和新兴研究方向。

Objective

Based on bibliometric methods, a visualized analysis of research related to ferroptosis in colorectal cancer was conducted to explore the research hotspots and development trends in this field from 2017 to 2024.

Methods

Relevant literature published from January 1, 2017 to December 31, 2024 in the Web of Science Core Collection, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases were retrieved. The publication volume, countries, institutions, journals, and keywords were visualized by CiteSpace 6.4.R1 and Microsoft Excel 2016. Co-occurrence and clustering analysis of keywords were also performed.

Results

A total of 739 articles were included, with 598 in English and 141 in Chinese. The analysis results showed that the number of papers published from 2017 to 2019 was relatively low, but the number has increased since 2020. Globally, China is the country with the most papers published,Fudan University is the institution with the highest number of papers published, and Frontiers in Oncology is the journal that publishes the most such studies. Co-occurrence and clustering analysis of keywords identified four core research themes: the molecular mechanisms and metabolic regulation of ferroptosis, the expression and signaling pathway regulation of ferroptosis-related genes, ferroptosis and tumor immune regulation, and clinical therapeutic strategies and interventions based on ferroptosis. Keyword emergence analysis showed that ferroptosis regulation mechanism and metabolic regulation are continuous research hotspots in this field. In recent years, the research focus has gradually shifted to clinical applications, with particular attention paid to the research on endoplasmic reticulum stress, stem cell technology, photodynamic therapy, and inflammatory response.

Conclusion

The research on ferroptosis in colorectal cancer is in a rapid development stage, the exploration of the mechanism of ferroptosis in colorectal cancer and its clinical application are current research hotspots and emerging research directions.

图1 2017 年至2024 年发文量变化趋势图谱
表1 Web of Science 核心数据库中发文量排名前10 位的国家
图2 Web of Science 核心数据库中国家合作网络图谱
表2 Web of Science 核心数据库发文量排名前10 位的机构
图3 Web of Science 核心数据库中机构合作网络图谱
表3 Web of Science 核心数据库发文量排名前10 位的期刊
图4 Web of Science 核心数据库中期刊双叠加可视化图谱
表4 CNKI、万方、维普数据库中高频和高中介中心性关键词
表5 Web of Science 核心数据库中高频和高中介中心性关键词
图5 CNKI、万方、维普数据库中核心关键词网络共现图谱
图6 Web of Science 核心数据库中核心关键词网络共现图谱
表6 CNKI、万方、维普数据库中中关键词聚类分析明细
表7 Web of Science 核心数据库中关键词聚类分析明细
图7 CNKI、万方、维普数据库中核心关键词聚类时间线图谱
图8 Web of Science 核心数据库中关键词聚类时间线图谱
图9 Web of Science 核心数据库中核心关键词突现图谱
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